Kawa pyrones

Pharmacological Profiles of Anxiolytics and Sedative—Hypnotics. Historically, chemotherapy of anxiety and sleep disorders rehed on a wide variety of natural products such as opiates, alcohol, cannabis, and kawa pyrones. Use of various bromides and chloral derivatives ia these medical iadications enjoyed considerable popularity early ia the twentieth century. Upon the discovery of barbiturates, numerous synthetic compounds rapidly became available for the treatment of anxiety and insomnia. As of this writing barbiturates are ia use primarily as iajectable general anesthetics (qv) and as antiepileptics. These agents have been largely replaced as treatment for anxiety and sleep disorders. 

The success of this strategy depends on the availability of open-chain materials containing all the carbon atoms possessing the required functionality. Borsche and Bodenstein adopted this type of closure to prepare pyrones of the Kawa family (29CB2515 62FOR131), but they used open-chain precursors obtained by degradation of the same Kawa pyrones in an attempt to elucidate their structures. 

Some families of natural products within the framework of this review should be considered. Thus, the so-called kawa pyrones have attracted considerable attention during the first half of this century. They are com-... 

We present in Table IV the trivial names of all pyrones not categorized as kawa pyrones. Three headings appear in Table IV (a) Structure, including structural elucidation. References for isolation procedures and natural sources can be found, since they are quoted in the papers dealing with structure elucidations. Therefore, they have been omitted in this review ... 

Meyer, H.J. and Kretzschmar, R. (1969) Untersuchungen iiber Beziehungen zwischen Moleku-larstruktur und pharmakologischer Wirkung Cg-arylsubstituierter 4-Methoxy-a-pyrone vom Typ der Kawa-Pyrone. Arzneimittelforschung, 19, 617—623. 

Kretzschmar, R., Meyer, J., Teschendorf, H.J. and Zollner, B. (1969) Antagonistische Wirkung natiirlicher 5,6-hydrierter Kawa-Pyrone auf die Strychninvergidtung und den experimentellen lokalen Tetanus. Archives Internationales des Pharmacodynamie, 182(2), 251-268. 

Meyer, H.J. (1964) Untersuchungen liber den antikonvulsiven Wirkungstyp der Kawa-Pyrone Dihydromethysticin und Dihydrokawain mit Hilfe chemisch induzierter Krampfe. Archives Internationales des Pharmacodynamie, 150(1—2), 118—131. 

Meyer, H.J. and May, H.U. (1964) Lokalanaesthetische Eigenschaften natlirlicher Kawa-Pyrone. Klinische Wochenschrift, 8, 407. 

Some pyrones of the general Kawa structure dimerize on irradiation, even under day light. Although the double bond in the side chain at C6 is. 

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