Physiologic dose

Stop the glucocorticoid when the equivalent physiologic dose is reached (20 mg/day of hydrocortisone or 5-7.5 mg/day of prednisone or equivalent). 

Intraspecies 3—The test is optimized there is a built in safety factor because of the greater-than-physiological dose of epinephrine administered. In addition, there is no data indicating individual differences in sensitivity. ... 

Humans exposed at high concentrations of some halogenated hydrocarbons can develop cardiac arrhythmias. The cardiac sensitization test in dogs is considered an effective determination of potential cardiac sensitization in humans. Cardiotoxicity was observed at concentrations well below those associated with any acute toxic signs but only in the presence of greater-than-physiological doses of exogenous epinephrine. 

These above-mentioned studies quantifying bile acid reflux have been fundamental to allowing in vitro analysis of bile acid effects at physiological doses (Table 6.2). These in vitro studies have crucially, identified molecular mechanisms important in bile-driven carcinogenesis. These molecular events will undoubtedly be important in future years as drug-able targets and as biomarkers of cancer risk. Prior to bile acid quantification in the refluxate, there... 

C) The physician should rapidly reduce glucocorticoid therapy to physiological doses. 

The changes in calvarial phosphatase activities observed in animals treated with 25-(OH)D3 are totally different from those obtained with either 1.25-(OH)2D3 or 24.25—(OH)2D3. This fact indicates that physiological doses of 25-(OH)D3 may have an effect on cellular activity, independent of the conversion of this metabolite into these dihydroxyderivatives. The various effects of these vitamin D3 metabolites cannot be correlated with changes in serum calcium and/or phosphate concentrations. Among those factors other than serum calcium and phosphate concentrations that may be involved in the mechanism of action of vitamin D3 metabolites on bone phosphatase activities, the parathyroid hormone is of importance. This hormone is known to be a potent activator of bone phosphatases223,224,228. Parathormone increases the content of alkaline, neutral and acid phosphatases in mouse calvaria in vitro. Calcitonin does not prevent the increase of those enzymes while dichloromethylene diphosphonate causes a decrease in acid phosphatase and pyrophosphatase226. ... 

Physiologic dose The amount of drug given that is roughly equivalent to the amount of a similar substance normally produced within the body this dose is typically used to replace the endogenous substance when the body is no longer able to produce the substance. 

DeLean A, Munson PJ, Rodbard D (1978) Simultaneous analysis of families of sigmoidal curves Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235 E97-E102... 

Early studies showed that, after the administration of [ H]cholecalciferol or ergocalciferol to vitamin D-deficient animals, there is marked accumulation of [ H] calcitriol in the nuclei of intestinal mucosal cells. Physiological doses of vitamin D cause an increase in the intestinal absorption of calcium in deficient animals the response is faster after the administration of calcidiol and faster stUl after calcitriol. There are two separate responses of intestinal mucosal cells to calcitriol a rapid increase in calcium uptake that is due to recruitment of calcium transporters to the cell surface (Section 3.3.2) and a later response from the induction of a calcium binding protein, calbindin-D. 

You, C. H., Rominger,). M and Chey, W, . (1983). Potentiation effect of choiccystokinin-octapeptide on pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin in humans. Cssfrotfilitm/ogy 85, 40-45. 

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