Photodynamic disease

ScHENCK GO (1985) is the New Forest Decline a Photodynamic Disease Caused by light and Peroxyacetylnitrate, Ozone, Ha-locarbons and Others , Europ. Photochem. Assoc. Nemslett., No. 23/24 15-41. 

Blum, H. F. Photodynamic Action and Diseases Caused by Light, American Chemical Society Monograph Series No. 85 Reinhold New York, 1941. 

Porphyrins 21 are the backbone of major players in life cycles—cytochromes (Scheme 8). There are three types of cytochromes, classified by their color, or more precisely by their long-wavelength absorption band, as a (600 mn), b (563 nm), and c (550 nm). They are protein conjugates of a porphyrin complex with iron(II), which is a coenzyme called heme (22). In plants, porphyrins form a complex with magnesium-(II) chlorophylls a and b (23), vital in photosynthesis. Porphyrin derivatives are used in photodynamic therapy for dermatological diseases such as psoriasis, and for skin or subcutaneous cancer.5c-e... 

Flamblin MR, Hasan T (2004) Photodynamic therapy a new antimicrobial approach to infectious disease 3 436—450. 

Presently photodynamic therapy (PDT) is considered as a perspective way for therapy of different diseases, including cancer. PDT is a method based on the local light-induced activation of photosensitizers able to accumulate selectively in energy-deficient cells (malignant or dysplastic ones) not influencing the remaining normal cells of the body (Pass, 1993). Upon the action of irradiation of certain wavelength characteristic for individual photosensitizer, photochemical reaction occurs... 

Le Doan T, Perrouault L, Rougee M, Bensasson RV, Helene C (1985) In Jori G, Perria C (eds) Photodynamic Therapy of Tumours and other Diseases, Libreria Progetto, Padova, p 56... 

Hamblin, M. R. and Hasan, T. (2004). Photodynamic therapy A new antimicrobial approach to infectious disease. Photochem. Photobiol. Sci. 3, 436-450. 

This photodynamic compound causes a photosensitive disease called bighead in sheep that consume it (42). Related compounds, the... 

Photodynamic therapy (PDT) is a developing approach to the treatment of cancer and certain other diseases, such as age-related macular degeneration, which uses a combination of a photosensitizing dye and laser light to obtain a therapeutic effect [75], There is also an absolute requirement for oxygen. If any of the... 

Motexafin lutetium is also in clinical trials, having completed several Phase I and II studies. The completed trials are for the photodynamic treatment of recurrent breast cancer [41,42], light-based treatment of choroidal neovascularization, [43] and the photoangioplastic reduction of atherosclerotic plaque in peripheral [19,44] and coronary arterial disease [20,45], On the basis of these studies, MLu (Antrin Phototherapy) is currently being developed for the treatment of atherosclerotic plaque. Additionally, the National Cancer Institute is testing MLu for the PDT based treatment of prostate [46,47] and cervical cancers. 

Chou, T.M. et al. (2002) Photodynamic therapy applications in atherosclerotic vascular disease with motexafin lutetium, Catheterization and cardiovascular interventions official journal of the Society for Cardiac Angiography Interventions 57, 387-394. 

Photodynamic therapy seems to offer broad applicability as either an adjunct to other endovascular procedures or as a means to treat de novo disease. At this juncture enough is known to imagine its potential without yet knowing its limitations. PDT could be an exciting tool for the emerging specialty of endovascular therapy, with potential applications in the heart, peripheral arteries, saphenous vein grafts, and arteriovenous grafts. 

Yamaguchi A, Woodburn KW, Hayase M, et al. Reduction of vein graft disease using photodynamic therapy with motexafin lutetium in a rodent isograft model. Circulation 2000 ... 

Wainwright M. Local treatment of viral disease using photodynamic therapy. IntJAnti-microb Agents 2003 21 510-20. 

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