Phenylhydrazones reduction

Acetophenone similarly gives an oxime, CHjCCgHjlCtNOH, of m.p. 59° owing to its lower m.p. and its greater solubility in most liquids, it is not as suitable as the phenylhydrazone for characterising the ketone. Its chief use is for the preparation of 1-phenyl-ethylamine, CHjCCgHslCHNHj, which can be readily obtained by the reduction of the oxime or by the Leuckart reaction (p. 223), and which can then be resolved by d-tartaric acid and /-malic acid into optically active forms. The optically active amine is frequently used in turn for the resolution of racemic acids. 

The acetone test reagent consists of a 0 1 per cent, solution of 2 4-dinitro-phenylhydrazine and is prepared as follows Dissolve 0-25 g. of 2 4-dinitrophenyl-hydrazine in 60 ml. of water and 42 ml. of concentrated hydrochloric acid by warming on a water bath cool the clear yellow solution and dilute to 250 ml. with water. The acetone test is considered negative when 5 ml. of the reagent and 4-5 drops of the distillate give no cloudiness or precipitate of acetone 2 4-dinitro-phenylhydrazone within 30 seconds. After a negative test is obtained, it is stron y recommended that the mixture in the flask be refluxed for 5-10 minutes with complete condensation and then to collect a few drops of distillate for another test. If no acetone is now detected, the reduction is complete. 

The present procedure was developed from those of Wallach and Freylon, based upon the general method discovered by Leuckart. a-Phenylethylamine also can be prepared satisfactorily by the reduction of acetophenone oxime with sodium and absolute alcohol or sodium amalgam, but the reagents are more expensive and the processes less convenient. The amine has been obtained by reducing acetophenone oxime electro-lytically, by reducing acetophenone phenylhydrazone with sodium amalgam and acetic acid, from a-phenylethyl bromide and hexamethylenetetramine, and by the action of methyl-magnesium iodide upon hydrobenzamide, as well as by other methods of no preparative value. 

Reductive cleavage of phenylhydrazones of carbonyl compounds provides a route to amines. The reduction is carried out conveniently in ethanol containing ammonia over palladium-on-carbon. Ammonia is used to minimize formation of secondary amines, derived by addition of the initially formed amine to the starting material (160). Alternatively, a two-phase system of benzene, cyclohexane, toluene, or dioxane and aqueous hydrochloric acid can be used. 

The well-known triphenyltetrazolium chloride (TTC) reaction for the detection of a-ketolsteroids, pyridinium carbinols and pyridinium glycols can also be included here [20-23]. The chromophore system of the red-colored formazan dye produced by reduction of the TTC is composed of highly conjugated double bonds resulting from the combination of a phenylhydrazone group with an azo group ... 

The reason for the rate increase in the presence of phenylhydrazine remains unclear. The authors note that phenylhydrazone also accelerates the reaction and that the formation of the hydrazone from the solvent (acetone) cannot be ignored. Phenylhydrazine is known to reduce Cu(II) to Cu(I) (115), and the authors observed that the hydrazone is also capable of this reduction. It is interesting that the same rate acceleration could not be induced by other amine bases such as pyridine, l,5-diazabicyclo[4.3.0]non-5-ene (DBN), or DBU. While it is likely that phenyl-hydrazine-phenylhydrazone accelerates the slow step of the catalytic cycle through some sort of interaction with the metal, the exact nature of this involvement remains unclear. Elucidation of its role in the reaction may greatly aid the development of this transformation, and it is expected that it will impact the ultimate solution to this problem. 

Reductions with aluminum are carried out almost exclusively with aluminum amalgam. This is prepared by immersing strips of a thin aluminum foil in a 2% aqueous solution of mercuric chloride for 15-60 seconds, decanting the solution, rinsing the strips with absolute ethanol, then with ether, and cutting them with scissors into pieces of approximately 1 cm [141,142]. In aqueous and non-polar solvents aluminum amalgam reduces cumulative double bonds [143], ketones to pinacols [144], halogen compounds [145], nitro compounds [146, 147], azo compounds [148], azides [149], oximes [150] and quinones [151], and cleaves sulfones [141, 152, 153] and phenylhydrazones [154] (Procedure 30, p. 212). 

Hydrazones treated with alkalis decompose to nitrogen and hydrocarbons [845, 923] Woljf-Kizhner reduction) (p. 34), and p-toluenesulfonylhydra-zones are reduced to hydrocarbons by lithium aluminum hydride [812], sodium borohydride [785] or sodium cyanoborohydride [813]. Titanium trichloride hy-drogenolyzes the nitrogen-nitrogen bond in phenylhydrazones and forms amines and ketimines which are hydrolyzed to the parent ketones. Thus 2,4-dinitrophenylhydrazone of cycloheptanone afforded cycloheptanone in 90% yield [202]. 

Large-scale reduction of phenylhydrazones at mercury or lead in ethanolic hydrochloric acid or 30-50% sulphuric acid results in cleavage of the nitrogetr-... 

Reduction of dehydro-c-ascorbic acid phenylhydrazone (40) with LiAlH4 resulted in hydrogenation of the hydrazone residue and cyclization to bicyclic compound 41, which was dehydrogenated with boiling acetic anhydride during acetylation to give diacetate 43, then partly hydrolyzed to monoacetate 42 (Scheme 7) (72JOC3523). 

Another 2,3-bis(phenylhydrazone), namely, l,5 4,6-dianhydro-2,3-hexodiulose bis(phenylhydrazone) (62a), was also found to cyclize to a pyrazoline (63a) by the action of copper(II) sulfate or benzalde-hyde, which usually convert osazones into aldosuloses or osotria-zoles.65 Reduction of this bicyclic compound (63a) led to the pyrazo-lidine 64, and periodate oxidation of 63a gave the expected aldehyde 65. 

Phenylhydrazone formation indicates a carbonyl compound. Since the negative Tollens test rules out an aldehyde, (A) must be a ketone. A negative iodoform test rules out the CH,C=0 group, and the reduction product, pentane, establishes the C s to be in a continuous chain. The compound is CHjCHjCOCHjCH,. 

Amide reduction with lithium aluminum hydride, 39, 19 Amine oxide formation, 39, 40 Amine oxide pyrolysis, 39, 41, 42 -Aminoacetanilide, 39, 1 Amino adds, synthesis of, 30, 7 2-Amino-4-anilino-6-(chloro-METHYl) -S-TRIAZINE, 38, 1 -Aminobenzaldehyde, 31, 6 hydrazone, 31, 7 oxime, 31, 7 phenylhydrazone, 31, 7 > -Aminobenzoic add, 36, 95 2-Aminobenzophenone, 32, 8 c-Aminocaproic acid, 32, 13 6-Aminocaproic acid hydrochloride,... 

Acetonitrile, 407 Acetophenone, 725,729,730 phenylhydrazone, 852 p-Acetotoluidide, 593, 605 Acetoxime, 343 Acetylacetone, 861, 862, 863 Acetylation, reductive, 749 Thiele, 749 Acetyl chloride, 367 2-Acetylcyciohexanone, 862, 864 Acetylene, 245, 897 reactions of, 245, 246 Acetylenic compounds, synthesis of, 467-469, 895-902 Acetylglycine, 909 Acetylmethylurea, 968, 969 Acetylsalicylio acid, 996 Acetyl-o-toluidide, 578 2-Acetylthiophene, 837 Acid anhydrides of aliphatic carboxylic acids, 371... 

Uramil has been obtained by boiling alloxantin with ammonium chloride 1 by reduction of nitrosobarbituric acid or ryjtro-barbituric acid with hydrogen iodide 2 and by reduction of alloxan phenylhydrazone with tin and hydrochloric acid.3... 

Substituents on thiocoumarins behave in predictable fashion for example, 3-nitro compounds afford the 3-amines on reduction, while 3-acyl derivatives readily form normal carbonyl derivatives such as phenylhydrazones, or enoic acids with malonates. These derivatives may frequently be cyclized on to position 4 of a 4-hydroxythiocoumarin to give products such as (119) (equation 59). 

Carbonyl groups can be transformed into amines via formation of their hydrazones followed by transfer hydrogenation. Thus the benzoyl formate shown in Scheme 4.35 was converted into the phenylhydrazone under microwave irradiation in ethylene glycol as solvent. Subsequent reduction using ammonium formate and 10% Pd/C as a catalyst provides the amine in an overall reaction time of 10 min and a total yield of 83%.14... 

Adopting an alternative convergent strategy, the two key halves of (446) were readily assembled as shown. Catalytic reduction of (219) with phenylhydrazine produced an intermediate phenylhydrazone which smoothly exchanged with /i-nitrobenzaldehyde to give (444). Conversion of /i-toluoyl chloride to the phosphonium salt (445) was straightforward. Wittigcondensation of (445) with (444) followed by catalytic reduction and saponification afforded (446). 

The Fischer cyclization of phenylhydrazones of structure (18) gives rise to the carbinolamine-lactones (19). Reaction with methylamine, followed by reduction, then affords a short synthesis of esermethole (20a) and eserethole (20b) (Scheme... 

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