Phenyl 1-phenylethyl ketone

Ethyl p-phenylethyl ketone. Use 100 g. of pure hydrocinnamic acid and 200 g. (201 -5 ml.) of pure propionic acid. Fractionation of the distillate yields 70 g. of diethyl ketone (b.p. 100-102°), 72 g. of ethyl p-phenyl-ethyl ketone (b.p. 245-249° the pure ketone boils at 248°), and 18 g, of crude di-p-phenylethyl ketone (high b.p. residue). 

The CIDNP technique has led to similar conclusions about the precursor multiplicity for methyl benzyl ketone (Blank et al., 1971). With dibenzyl ketone and phenyl a-phenylethyl ketone (Closs, 1971a Muller... 

CAS 2550-26-7 EINECS/ELINCS 219-847-4 Synonyms 2-Butanone, 4-phenyl- Methyl phenethyl ketone Methyl phenylethyl ketone Methyl 2-phenylethyl ketone Phenethyl methyl ketone... 

Methyl phenylethyl ketone Methyl 2-phenylethyl ketone. See Benzylacetone 3-Methyl-3-phenyl glycidic acid ethyl ester. See Ethyl methylphenylglycidate Methylphenylglyoxal. See 1-Phenyl-1,2-propanedione Methyl phenylglyoxalate CAS 15206-55-0 EINECS/ELINCS 239-263-3 Synonyms Benzeneacetic acid, a-oxo-, methyl ester Methylbenzoylformate Methyl a-ketophenylacetate Methylphenylglyoxylate Oxo-phenylacetic acid methyl ester Classification Aromatic ester Empirical CgHaOs... 

The rate of cyclization of o-(l-phenylethyl)phenyl alkyl ketone 1 (R = alkyl, Ri = Me, R2 = H) decreases steadily from methyl to n-butyl and then remains constant within the limit of experimental error. The major factor in the large decrease in rate of cyclization with increasing chain length is most likely steric interactions. 

Rates of cyclization of some o- -(l-phenylethyl)phenyl alkyl ketone 1 ... 

A noteworthy discrimination is between phenylethyl ketone and phenyl M-propyl ketone and between 3-heptanone and 4-heptanone. The presence of... 

Poly(l,4-pentadiene-alt-MA), 343, 348, 586 Poly(phenanthrene-alt-MA), 376, 660 Poly(phenylacetylene), MA grafted, 471 Poly(phenylacetylene-co-MA), 335, 660 Poly(2-phenylallyl alcohol-alt-MA), 331, 660 Poly(4-phenyl-l-butene-alt-MA), 340, 341 Poly(/- 1-phenylethyl methacrylate-co-MA), optically active polymer, 383 Poly(/-1-phenylethyl vinyl ether-alt-MA), optically active polymer, 383 Poly(5-phenyl-l-pentene-alt-MA), 340, 341 Poly( l-phenyl-4-pentene- 1-one-alt-MA), 314 Poly(3-phenyl propene-l-alt-MA), 341 Poly(o-phenylstyrene-alt-MA), 373 Poly(2-phenylvinyl alkyl ethers-alt-MA), 318 Poly(2-phenylvinyl alkyl thioethers-alt-MA), 318 Poly(phenyl vinyl ether-alt-MA), 318, 394 Poly(phenyl-o-vinyl formal-alt-MA), 328 Poly(phenyl vinyl ketone-co-MA), physical properties, 290... 

No stereoselectivity was observed in the formation of a 1 1 diastereomeric mixture of 2-hydroxy-2-phenylethyl p-tolyl sulfoxide 145 from treatment of (R)-methyl p-tolyl sulfoxide 144 with lithium diethylamide . However, a considerable stereoselectivity was observed in the reaction of this carbanion with unsymmetrical, especially aromatic, ketones The carbanion derived from (R)-144 was found to add to N-benzylideneaniline stereoselectivity, affording only one diastereomer, i.e. (Rs,SJ-( + )-iV-phenyl-2-amino-2-phenyl p-tolyl sulfoxide, which upon treatment with Raney Ni afforded the corresponding optically pure amine . The reaction of the lithio-derivative of (-t-)-(S)-p-tolyl p-tolylthiomethyl sulfoxide 146 with benzaldehyde gave a mixture of 3 out of 4 possible isomers, i.e. (IS, 2S, 3R)-, (IS, 2R, 3R)- and (IS, 2S, 3S)-147 in a ratio of 55 30 15. Methylation of the diastereomeric mixture, reduction of the sulfinyl group and further hydrolysis gave (—)-(R)-2-methoxy-2-phenylacetaldehyde 148 in 70% e.e. This addition is considered to proceed through a six-membered cyclic transition state, formed by chelation with lithium, as shown below . ... 

Methoxyphenyl 2-Oxo-2-phenylethyl Tellurium Dichloride1 0.34 g (1 mmol) of 4-mcthoxyphenyl tellurium trichloride and 0.36 g (3 mmol) of methyl phenyl ketone are intimately mixed and allowed to stand for 48 h. During this time the product crystallizes. Diethyl ether is added to the mixture which is then shaken thoroughly. The ether is decanted, the crystals are quickly washed with a small amount of cold methanol, and recrystallized from benzene/petroleum ether (b.p. 50-70°) yield 0.25 g (60%) m.p. 137". 

A methodically related transformation, the copper(Il)-mediated transfer of a cyano(ethoxycar-bonyl)methylene unit from ethyl cyanoacetate to alkenes, is presented in Section I.2.I.2.4.2.9. The copper-mediated synthesis of cyclopropyl ketones from a,a-dibromo ketones and alkenes seems to be of very limited scope and even less efficient than the corresponding synthesis of cyclopropanecarboxylic acids from o ,a-dibromoacetates (vide supra). The reaction (toluene, 100°C, 93 h) of cyclooctene (4.0 mmol), dibromomethyl phenyl ketone (8.0mmol), and commercial grade copper powder (18 mmol) activated with iodine (0.2 mmol) gave exy-9-benzoyl-bicyclo[6.1.0]nonane (7, 12%) and (2-oxo-2-phenylethyl)cyclooct-l-ene (8, 3%). ° A similar treatment of styrene gave l-benzoyl-2-phenylcyclopropane in only 2% yield [ratio (cisjtrans) 1 l.b]. " ... 

Aminomethyl phenyl ketone oximes, such as ethyl 6-amino-5-nitro-4- [2-(hydroxyimino)-2-phenylethyl]amino pyridine-2-carbamate, bearing various substituents in the phenyl group are converted into the corresponding ketones 12, and then cyclized by hydrogenating the nitro function to yield 5-amino-3-aryl-1,2-dihydropyrido[3,4-5]pyrazine-7-carbamates 13.104 1°9... 

Phenyl-3-butanone 4-Phenylbutan-2-one 4-Phenyl-2-butanone p-Phenylethyl methyl ketone... 

Phenylethyl methyl ethyl carbinol. See 1-Phenyl-3-methyl-3-pentanol Phenylethyl methyl ethyl carbinol acetate. See Phenethyl methyl ethyl carbinyl acetate P-Phenylethyl methyl ketone. See Benzyl acetone... 

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