Methyl /3-phenylethyl ketone

CAS 2550-26-7 EINECS/ELINCS 219-847-4 Synonyms 2-Butanone, 4-phenyl- Methyl phenethyl ketone Methyl phenylethyl ketone Methyl 2-phenylethyl ketone Phenethyl methyl ketone... 

Methyl phenylethyl ketone Methyl 2-phenylethyl ketone. See Benzylacetone 3-Methyl-3-phenyl glycidic acid ethyl ester. See Ethyl methylphenylglycidate Methylphenylglyoxal. See 1-Phenyl-1,2-propanedione Methyl phenylglyoxalate CAS 15206-55-0 EINECS/ELINCS 239-263-3 Synonyms Benzeneacetic acid, a-oxo-, methyl ester Methylbenzoylformate Methyl a-ketophenylacetate Methylphenylglyoxylate Oxo-phenylacetic acid methyl ester Classification Aromatic ester Empirical CgHaOs... 

Methyl malonatc, 13, 100 Methyl 0-naphthyl ketone, 17, 65 Methyl nitrite, 16, 44 Methyl oxalate, 10, 70 3-Methylpentanoic acid, 11, 76 Methyl 0-phenylethyl ketone, 16, 49... 

The CIDNP technique has led to similar conclusions about the precursor multiplicity for methyl benzyl ketone (Blank et al., 1971). With dibenzyl ketone and phenyl a-phenylethyl ketone (Closs, 1971a Muller... 

Unsymmetrical ketones containing Ar and OAr substituents in the alkyl radicals behave differently in the Pfitzinger reaction. Thus, methyl p-phenylethyl ketone reacts with isatin 7 in the presence of potassium hydroxide in water and alcohol through the methyl group - a single product 2-(P-phenylethyl)-4-quinolinecarboxylic acid is formed with a yield of 79% [22, 32],... 

Methoxyphenyl 2-Oxo-2-phenylethyl Tellurium Dichloride1 0.34 g (1 mmol) of 4-mcthoxyphenyl tellurium trichloride and 0.36 g (3 mmol) of methyl phenyl ketone are intimately mixed and allowed to stand for 48 h. During this time the product crystallizes. Diethyl ether is added to the mixture which is then shaken thoroughly. The ether is decanted, the crystals are quickly washed with a small amount of cold methanol, and recrystallized from benzene/petroleum ether (b.p. 50-70°) yield 0.25 g (60%) m.p. 137". 

Using the same procedure the following ketones may be obtained in similar yields ethyl benzyl ketone from phenylacetic acid and propionic acid, methyl 8-phenylethyl ketone from hydrocinnamic acid and acetic acid, and ethyl /3-phenylethyl ketone from hydrocinnamic acid and propionic acid. 

P-Methylphenethyl butyrate. See2-Phenylpropyl butyrate Methyl phenethyl ether Methyl 2-phenethyl ether. See 2-Phenylethyl methyl ether Methyl phenethyl ketone. See Benzylacetone... 

No stereoselectivity was observed in the formation of a 1 1 diastereomeric mixture of 2-hydroxy-2-phenylethyl p-tolyl sulfoxide 145 from treatment of (R)-methyl p-tolyl sulfoxide 144 with lithium diethylamide . However, a considerable stereoselectivity was observed in the reaction of this carbanion with unsymmetrical, especially aromatic, ketones The carbanion derived from (R)-144 was found to add to N-benzylideneaniline stereoselectivity, affording only one diastereomer, i.e. (Rs,SJ-( + )-iV-phenyl-2-amino-2-phenyl p-tolyl sulfoxide, which upon treatment with Raney Ni afforded the corresponding optically pure amine . The reaction of the lithio-derivative of (-t-)-(S)-p-tolyl p-tolylthiomethyl sulfoxide 146 with benzaldehyde gave a mixture of 3 out of 4 possible isomers, i.e. (IS, 2S, 3R)-, (IS, 2R, 3R)- and (IS, 2S, 3S)-147 in a ratio of 55 30 15. Methylation of the diastereomeric mixture, reduction of the sulfinyl group and further hydrolysis gave (—)-(R)-2-methoxy-2-phenylacetaldehyde 148 in 70% e.e. This addition is considered to proceed through a six-membered cyclic transition state, formed by chelation with lithium, as shown below . ... 

The facile reaction of CAA and BAA with nucleosides and nucleotides is one example of many of the applications of the bifunctional reactivity of halogenated aldehydes and ketones in modification of biomolecules. In an early example of the extensive use of halogenated ketones as protease substrate analogues, l-V-tosylamido-2-phenylethyl chloro-methyl ketone (TPCK) 30 was synthesized as a chymotrypsin substrate analogue. Stoichiometric inhibition was accompanied by loss of one histidine residue as a result of alkylation by the chloromethyl moiety68. A host of similar analogues were subsequently prepared and used as selective enzyme inhibitors, in particular for the identification of amino acid residues located at enzyme active sites69. 

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