2-phenyl-, 2-hydroxyethyl

Treatment of 3-phenylperhydropyrido[ 1,2-/ 1,3 oxazin-l -one with LAH gave a 1 9.5 mixture of 3-phenylphenylper-hydropyrido[l,2-c][l,3]oxazine and l-methyl-2-(2-phenyl-2-hydroxyethyl)piperidine <20050BC520>. Reduction of ds- >,4a- I-/ra .v-8-H-3-incthyl-8-pentyIperhydropyrido[ 1 1,3 oxazin-6-onc with NaBH4 at room temperature... 

A somewhat different approach was reafized when using styrene oxide as the initial starting material. Reacting it with 2-imino-l,3-thiazolidine gives 3-(2-phenyl-2-hydroxyethyl)-2-imino-l,3-thiazofidine (31.1.5), which is subsequently treated with thionyl chloride and then acetic anhydride to give the desired levamisole (31.1.4). 

Two other ways of making levamisole differ only in the method of making l-(2-phenyl-2-hydroxyethyl)-2-imino-l,3-thiazolidine (38.1.28). One of them begins with a reaction of styrene oxide and 2-imino-l,3-thiazolidine and subsequent treatment of the resulting product (38.1.28) with thionyl chloride and then with acetic anhydride, which leads to the formation of tetramizole [25]. 

The main difference of one other way of making tetramizole of the above described, consists of carrying out the heterocyclization reaction in the presence of sodium hydroxide instead of acetic anhydride, which makes the possible mechanism of the heterocyclization more understandable. In the suggested method, l-(2-phenyl-2-hydroxyethyl)-2-imino-l, 3-thiazolidine (38.1.28) is made by reacting styrene oxide with ethanolamine, and subsequent... 

The treatment of a 5-oxoperhydropyrido[l,2-c][l,3]oxazine derivative with NaBH4 in MeOH afforded ds-4aH,5H-5-hydroxy derivative (06JOC8481, 06TL7923). Reduction of (3S,4 R)-(+)-3-phenyl-4,4fl,7,8-tetra-hydro-lH,3H-pyrido[l,2-c][l,3]oxazin-l-one with LAH gave ring-opened l-methyl-2-(2-phenyl-2-hydroxyethyl)-l,2,5,6-tetrahydropyridine (08S1033). 

SYNS ARSINE OXIDE, (m-CHLOROPHENYL)-HYDROXY(P-HYDROXYPHENETHYL)- 2-PHENYL-2-HYDROXYETHYL, m-CHLOROPHENYL ARSINIC ACID... 

C9H11N03 2-phenyl-2-hydroxyethyl carbamate 94-35-9 457.15 39.783 2 17110 C9H120 2-methyl-6-ethyl phenol 1687-64-5 487.15 45.3 1,2... 

S-(1-phenyl-2-hydroxyethyl)cysteine and S-(2-phenyl-2-hydroxyethyl)-cysteine, while the major biliary metabolite was the unchanged GSH conjugate mixture (see Table III). Urine also contained some of the mercapturlc acid, especially at the lowest dose, but this study suggests that winter flounder are relatively deficient In N-acetyl transferase activity for the cystelnyl conjugates. 

SO-CYS-GIY a mixture of S-(1-phenyl-2-hydroxyethyl)- and (2-phenyl-2-hydroxyethyl)-cystelnylglyclne. 

DinitrophenyI) -l-nitroxy-2-nitre-ethylol or a- 2,4-Dinitrophenyl)-j8-nitroethyl-nitrote. See under Phenyl-ethylol or Phenyl-hydroxyethyl and Derivatives... 

A reaction carried out by Haruki et al. is the energic oxidation of 5-(l-hydroxyethyl)2-phenylthiazole (5) in dioxane by aqueous Kl-iodine to give 2-phenyl-5-thiazolecarboxylic acid (6) (Scheme 2) (28). 

Thiazole, 4-methyl-5-(2-hydroxyethyl)-in thiamine biosynthesis, 1, 97 Thiazole, 4-methyl-2-methylami nosynthesis, 6, 300 Thiazole, 4-methyl-2-phenyl-alkylation, 6, 256 mercuration, 6, 256 Thiazole, 2-(methylthio)-methylation, 6, 290 thermodynamic values, 6, 291 Thiazole, 2-methylthio-5-phenyl-synthesis, 5, 153 Thiazole, 4-methyl-5-vinyl-occurrence, 6, 327 Thiazole, 2-phenyl-acetylation, 6, 270-271 Conformation, 6, 237 synthesis, 5, 113, 6, 306 Thiazole, 4-phenyl-conformation, 6, 237 2,5-disubstituted synthesis, 6, 304 Thiazole, 5-phenyl-conformation, 6, 237 Thiazole, 2-phenyl-5-triphenylmethyl-synthesis, 6, 265 Thiazole, 2-(2-pyridyl)-metal complexes, 5, 51 6, 253 Thiazole, 4-(2-pyridyl)-metal complexes, S, 51 6, 253 Thiazole, tetrahydro-ring cleavage, 5, 80 Thiazole, 2,4,5-trimethyl-occurrence, 6, 327... 

Condensation of the TV-substituted p-aminocrotonic acid ester 15 with p-benzoquinone (4) has been successfully carried out to furnish the 5-hydroxyindole 29 when the substituent R on the nitrogen of the aminocrotonic acid ester was methyl, ethyl, -propyl, isopropyl, or -butyl, -hexyl, p-cyanoethyl, p-hydroxyethyl, carbethoxymethyl, benzyl, phenyl, o-tolyl, dimethylaminopropyl, y-hydroxypropyl etc ... 

A single stereoisomer of 4-methyl-3-phenylperhydropyrido[2,l-c][l,4]oxa-zine 279, containing a fused bicycle, was obtained by the cyclization of l-(2-hydroxyethyl)-2-piperidinemethanol 235 in CH2CI2 on the action of cone. H2SO4 (97JHC1813). Similarly, l-phenylperhydropyrido[2,l-c][l,4] oxazine 281 was obtained from l-(2-hydroxyethyl)-2-[(phenyl)hydroxy-methyljpiperidine 280. 

The N-[/3-(o-chlorophenyl)-/3-hydroxyethyl] -isopropylamine obtained by the foregoing procedure was dissolved in about 3 liters of ether and dry hydrogen chloride gas was bubbled into the solution until it was saturated, whereupon the hydrochloride salt of N-[/3-(o-chloro-phenyl)-/3-(hydroxy)-ethyl] isopropylamine precipitated. The salt was separated from the ether by filtration, and was dissolved in two liters of anhydrous ethanol. The alcoholic solution was decolorized with charcoal and filtered. 

Segmented poly(ether urethanes) were synthesized from polypropylene glycol (PPG) and 4,4 methylene-bis(phenyl-isocyanate) (MDI), using l,l -bis(B-aminoethyl)ferrocene (1) and 1,1 -bis(B-hydroxyethyl)-ferrocene (2) as chain extenders. 

In one example of this type of cyclization aminoalcohol, 288, which was obtained by conjugate addition of racemic 2-(2-hydroxyethyl)piperidine to allyl phenyl sulfone, was converted into the corresponding chloride and cyclized in the presence of LDA to give 289 as a single diastereomer (Scheme 63) <2003JOC9389>. In a related approach, the primary alcohol group was activated for a similar cyclization by transformation into a mesylate <20010L2957>. 

Heating l-(2-hydroxyethyl)-2-(Taryl-l-hydroxymethyl)-3-bcnzyloxy-l, 4-dihydro-pyridinH-oncs and l-(2,2-dimethoxyethyl)-2-[1-phenyl-1-(2-pyranyloxy)methy l]-3-bcnzy loxy-1,4-dihydropy rid inM-onc in acidic media gave... 

In this work, the kinetics of these reactions are closely examined by monitoring photopolymerizations initiated by a two-component system consisting of a conventional photoinitiator, such as 2,2-dimethoxy-2-phenyl acetophenone (DMPA) and TED. By examining the polymerization kinetics in detail, further understanding of the complex initiation and termination reactions can be achieved. The monomers discussed in this manuscript are 2-hydroxyethyl methacrylate (HEMA), which forms a linear polymer upon polymerization, and diethylene glycol dimethacrylate (DEGDMA), which forms a crosslinked network upon polymerization. 

The monomers studied, 2-hydroxyethyl methacrylate (HEMA) and diethylene glycol dimethacrylate (DEGDMA), were obtained from Aldrich (Milwaukee, WI) and Polysciences, Inc. (Warrington, PA), respectively, and were used after dehibition to remove the hydroquinone inhibitor. 2,2-Dimethoxy-2-phenyl acetophenone (DMPA), the conventional initiator used in this study, was obtained from Ciba-Geigy (Hawthorne, NY) and the tetraethylthiuram disufide (TED) was obtained from Aldrich. 

A procedure for estimating hexamethylene l,6-bis[l-(5-p-chloro-phenyl)biguanide] ( chlorohexidine") in the presence of anesthesine in tablets has been described (617). Nt,NiAnhydro[bis(p-hydroxyethyl)]-biguanide (616) and other biguanides (137) have been determined by spectrophotometric (137, 616) (including infra-red (563)) techniques. Chromatographic procedures have also been described (26, 449, 467). 

C8-2-HE C8-1-HE 8-Ph-dG 8-p-PhOH-dG 8-o-PhOH-dG 8-BP-dG 8-3,4-EQ-dG 8-Ar-dG 8-p-OMePh-dG C8-OPCP C8-CPCP dG-OTA dG-OTHQ 8-(2-hydroxyethyl)-2 -deoxyguanosine 8-(l-hydroxyethyl)-2 -deoxyguanosine 8-phenyl-2 -deoxyguanosine 8-(4"-hydroxyphenyl)-2 -deoxyguanosine 8-(2"-hydroxyphenyl)-2 -deoxyguanosine 8-(benzo[a]pyrene)-2 -deoxyguanosine... 

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