6-Phenyl-2- amine

A con jugated sp - -sp --" single bond (for example, the bond joining the tw o phenyl rings of biphenyl, the central bond of butadiene, with delocali/ed aromatic bonds, or phenyl amine, where N-G bond is labeled aromatic and nitrogen is sp2 b h ybridi/ed) IS described by a two-fold barrier, V2=l() kcal/mol. 

Note that the relative spatial arrangement of the phenyl, amine, and hydroxyl functionahties are identical for (R)-alprenolol and (5)-sotalol. In addition to P-blocking activities, some of these compounds also possess potent local anaesthetic activity (see Anesthetics). The membrane stabilizing activity, however, is not stereoselective and correlates directly with the partition coefficient (hydrophobicity) of the compound. 

Molecular rotors with a dual emission band, such as DMABN or A/,A/-dimethyl-[4-(2-pyrimidin-4-yl-vinyl)-phenyl]-amine (DMA-2,4 38, Fig. 13) [64], allow to use the ratio between LE and TICT emission to eliminate instrument- and experiment-dependent factors analogous to (10). One example is the measurement of pH with the TICT probe p-A,A-dimethylaminobenzoic acid 39 [69]. The use of such an intensity ratio requires calibration with solvent gradients, and influences of solvent polarity may cause solvatochromic shifts and adversely influence the calibration. Probes with dual emission bands often have points in their emission spectra that are independent from the solvent properties, analogous to isosbestic points in absorption spectra. Emission at these wavelengths can be used as an internal calibration reference. 

Hindered aliphatic aldehydes R CIIO (R1 = i-Pr or i-Bu) react with benzotriazole and anhydrous methanolic ammonia to yield the secondary amines 115, which are transformed into the phenylated amines 116 by the action of phenyllithium. Benzotriazole, aromatic aldehydes and ammonia give the imines 117, which react with lithium aluminium hydride to form dibenzylamines 118122. 

Microconcentrations of carcinogenic IV-nitrosamines were determined in various rubber articles (tubing, stoppers, hoses, seals, etc.) for medical and food uses by extraction followed by HPLC-FLD593. V-Nitrosodi phenyl amine (278c) present in diphenylamine formulations was determined by LC-TEA on a Zorbax CN column594. 

A variety of ligands were used to hydrogenate 73a, 74a-b, 75a-b, and 76a with moderate results. Steric interactions were magnified and that may explain why nearly all of the substrates in Scheme 15 give less than optimal results. A-methyl-A-phenyl-amine derived enamines 74a and 75a were resistant to hydrogenation where the analogous A-methyl-W-benzyl-amine-based enamines were completely converted with SimplePHOX ligand 77 with moderate enantioselectivity. 

These alkaloids have a phenyl or phenylpropyl nucleus. The group includes simple phenyl amine (tyramine, hordenine), catecholamine (dopamine, noradrenaline, adrenaline), simple tetrahydroisoquinoline (mescaline, anhalamine, anhalonine, anhalonidine), benzylisoquinoline (e.g., papaverine), phthalideiso-quinoline (e.g., noscapine), phenethylisoquinoline (autumnaline, floramultine and kreysigine), tetrahydroisoquinoline (emehne and cephaeline) and terpenoid tetrahydroisoquinoline (secologanin and ipecoside) alkaloids. 

Reaction of 4-chloro-6-fluoropyrido[3,4- pyrimidine 59 with [3-methyl-4-(pyridin-3-yloxy)phenyl]amine 60, followed by coupling the formed amine 61 with (3-azabicyclo[3.1.0]hex-6-yl)carbamic acid fi r7-butyl ester, afforded the substituted derivative 62 <2002EPP1249451>. Compound 59 was also reacted with 3-bromoaniline to give the 4-anilino derivative 63 that upon treatment with either methyl- or dimethylamine gave the corresponding 4,6-diamino derivatives 64 (Scheme 2) <1997W09726259, 1995W09519774>. 

Bei der Umsetzung von Hexafluorbenzol mit ein oder zwei Aquivalenten Lithium-amid in Tetrahydrofuran entsteht Pentafluor-anilin nur in sehr geringer Menge das Hauptpro-dukt ist Bis- pentafluor-phenyl]-amin (67%)7. 

Zugabe von geschmolzenem Formanilid zu einem heiBen Gemisch von Natrium und 4-Chlor-l-nitro-benzol in Toluol/Dimethylformamid und weiteres Erhitzen fuhrt zur Bil-dung von (4-Nitro-phenyl)-phenyl-amin (85-94%)2. 

X. ., -(4-nitroso-phenyl)-amin % Umwandlung, bez. auf 4-Nitroso-phenol... 

Allyl-phenyl-ether und Diallyl-ether werden in ahnlicher Weise gespalten, und zwar durch Diethylaminomagnesium-bromid unter Bildung von Allyl-diethyl-amin und durch Bis-[brommagnesium]-alkyl- (bzw. phenyl)-amin (in situ aus primarem Amin und Alkylma-... 

Nitro-arenc mil stark aktivierter Nitro-Gruppe reagieren mit Nitro-anilinen oder Amino-benzonitrilen zu Diphenylaminen, z.B. zu (2-Nitro-phenyl)-(4-nitro-phenyl)-amin (65-70%) oder (2,4-Dicyan-pkenyl)-(4-cyan-pkenyl)-amin (80%)1. 

Die elektrochemische Reduktion von Nitroso-benzolen (z. B. 4-Anilino-l-nitroso-benzol) und der lOfachen molekularen Menge Aceton in Wasser ergibt sekundare Amine (z.B. (4-Isopropylamino-phenyl)-phenyl-amin 95 %)3. 

OCH3 12 Ethyl- (4-methoxy-phenyl) -phenyl-amin 50... 

H3CO— -nh2 2,4,6-(CH,)s (2,4-Dimethoxy-phenyl)-(2,4,6-trimethyl-phenyl)-amin 74... 

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