Phenyl ethyl amine

The yields are based upon the amount of acetophenone initially used and do not make allowances for the material recovered from the steam distillation. A small amount of di-(a-phenyl-ethyl)-amine, b.p. 61-62°/2 mm., may be recovered from the residues. 

Trifluoroalanine has also been prepared by reducing trifluoropyruvate imines (ethyl trifluoropyruvate is available commercially it is prepared either from per-fluoropropene oxide or by trifluoromethylation of ethyl or f-butyl oxalate). These imines are obtained by dehydration of the corresponding aminals or by Staudinger reaction. They can also be obtained by palladium-catalyzed carbonylation of trifluoroacetamidoyl iodide, an easily accessible compound (cf. Chapter 3) (Figure 5.4). Reduction of the imines affords protected trifluoroalanines. When the imine is derived from a-phenyl ethyl amine, an intramolecular hydride transfer affords the regioisomer imine, which can further be hydrolyzed into trifluoroalanine. ... 

Benzyl-methyl-amtn Methyl- (2-phenyl-ethyl) -amin Cyclohexyl-methyl-amin Hexyl-methyl-amin... 

H1/Cr(CO)6/NaOCH /CH3OH 10000 kPa, 20° dann - 120r, 3 h Benzyi-( 1-phenyl-ethyl)-amin (100) 5... 

In addition to the mobile phase composition, the effect of other parameters such as temperature, flow rate, pH, and structure of the analytes were also studied, but only a few reports were available in the literature. In 1995, Lin and Maddox [66] studied the effect of temperature on the chiral resolution of amino acids and esters. The temperature was varied from 5°C to 25°C and it was reported that the resolution improved at low temperature. Hyun et al. [48-50,67] carried out the effect of temperature on the chiral resolution of amino alcohols, amines, fluoroquinolones, and other drugs. Again, lowering of temperature resulted in better resolution. The effect of temperature on the chiral resolution of phenylalanine, phenylglycine, and 2-hydroxy-2-(4-hydroxy-phenyl)-ethyl amine is shown in Table 5 [50], which indicates an increase in retention factors at lower temperature, but the best separation occurred at 20°C. These experiments indicated the exothermic nature of chiral resolution on CCE-based CSPs. Lin and Maddox [66] also studied the effect of flow rate on the chiral resolution of... 

TABLE 5 Effect of Temperature on the Chiral Resolution of Phenylalanine, Phenylglycine, and 2-Hydroxy-2-(4-hydroxy-phenyl)-ethyl Amine... 

In order to study substituent effects on the epimerization rate of square pyramidal compounds of the type CsHsM(CO)2LL, we synthesized the derivatives 41-49 by using instead of pyridine carbaldehyde-(2) the corresponding aldehydes for the condensation reaction with S-(-)-a-phenyl ethyl amine. In all the cases 41-49 the resulting pair of diastereoisomers could be separated into the optically active components a and b63-65 the a series is depicted in the formulas of Scheme 21. 

All amphetamines are synthetic, or manufactured, substances derived from alpha-methyl-beta-phenyl-ethyl-amine, a colorless liquid consisting of carbon, hydrogen, and nitrogen. In terms of their chemical structures, amphetamines are related to two natural substances known to boost energy within the human body. Those substances are ephedrine and adrenaline. Ephedrine is a natural stimulant found in plants of the genus Ephedra. It... 

Chlorophenyl) ethyl]amine-2-14 C (407) has been obtained by reduction of 405 with LAH-AICI3620. [2-[p- ( Trifluoromethyl)phenyl]ethyl]amine-2-14C(408) has been obtained similarly from 406. [2-[p-(Trifluoromethyl)phenyl]ethyl]amine-1-14C (409) has been obtained by reduction of 2-[/7-(trifluoromethyl)phenyl]ethanenitrile-l-14C by the same method. N,N-Dimethyl-N-[2-(p-chlorophenyl) ethyl]amine-2-14C has been obtained by reductive amination of 407621. N,N-Dimethyl-N-[2-(p-chlorophenyl)ethyl]amine-1 -14C, N, N-dimethyl-N-[2-[p- (trifluoromethyl)phenyl]ethyl]amine-2-14C and N,N-dimethyl-N-[2-[p-(chlorophenyl)phenyl]ethyl]amine-1-14C have been prepared by reductive amination of [2-(/ -chlorophenyl)ethyl]-amine-l-14C, 408 and 409, respectively. 

Two bases found in barley germs and in ergot are closely related compounds. Ergot is a fungus growth occurring on cereals, especially rye. From it several alkaloid substances have been isolated. One of these has been shown to be para-hydroxy phenyl ethyl amine. 

In like manner the higher homologues or mixed alkoxy-derivatives of phenyl ethyl amine may be made by reducing the corresponding 3,4,5-alkoxy-nitro-styrenes, that is to say such as contain higher or mixed alkoxy-groups. 

The alkaloids of Lophophora uilliamsii (Lem. ex SO) Coult, belong to the phenyl ethyl amine... 

Dimethyl-propyl-amin Dicthyl-(2-phenyl-ethyl)-amin Benzyl-dime thyl-amin Dimethyl-(4-methoxy-benzyl)-amin Bcnz°L ... 

Kappelmeier [35] has suggested the use of aniline, benzylamine, and phenyl-ethyl-amine as reagents for the identification and analysis of urea in UF resins. He has provided evidence that the methylene-ether groups form a bridge between urea residues in UF resins. The use of benzylamine in particular (which yields dibenzylurea from urea derivatives), has been developed as a method of analysis. In determining the ratio of urea to formaldehyde in UF resins, the benzylamine method has been coupled with a process of formaldehyde estimation which involves depolymerization with phosphoric acid, followed by distillation into alkaline potassium cyanide solution [36]. 

In this technique 2-phenyl ethyl amine is added to the reaction mixture and the ratio of the two diastereomeric amides formed from the excess of anhydride is determined gaschromatographically. We obtained in this way a negative peak increment with (+)-(R)-binaphthol, whereas the (-)-( )-compound gave a positive value (Table 1). 

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