Pyrimidine, 5-phenyl-, amination

Oxazolo[4,5-6]pyridin-2(3 H)-one IR, 6, 653 <76HCA1593) Oxazolo[4,5-fi]pyridin-2(3H)-one, 3-(4-chlorophenyl)-3a,7a-dihydro-6-methyl-X-ray, 6, 647 <79CPB2261) Oxazolo[4,5-6]pyridin-2(3H)-one, 3-(4-chlorophenyl)-3a,7a-dihydro-7a-methyl-X-ray, 6, 647 <79CPB2261) 5H-Oxazolo[3,2-a]pyridin-3(2H)-one, 2-phenyl-6,7,8,8a-tetrahydro-X-ray, 6, 646 <77MI42902) Oxazolo[5,4-d]pyrimidin-4-amine, A7-methyl- H NMR, 6, 650 <70BCJ3909)... 

Pyrimido[4,5-4]pyrimidin-4-amine, 7-(ethylmercapto)-2-phenyl-UV, 3, 338 (60JA5711)... 

Pyrimidin-2-amine, 4-ethyI-5-(2 -hydroxy-4 -nitrophenyI)-6-methyl-synthesis, 3, 121 Pyrimidin-2-amine, 4-methyl-basic pXj, 3, 61 Pyrimidin-2-amine, N-methyl-hydrolysis, 3, 84 synthesis, 3, 135 Pyrimidin-2-amine, 5-nitro-basic pXj, 3, 61 hydrolysis, 3, 84 Pyrimidin-2-amine, 4-phenyl-synthesis, 3, 109 Pyrimidin-2-amine, 5-phenyl-nitration, 3, 78... 

Pyrimidin-4-amine, 5-nitro-2-styryI-reduction, 3, 88 Pyrimidin-4-amine, 2-phenyl-hydrolysis, 3, 84 Pyrimidin-4-amine, 5-phenyI-synthesis, 3, 116 Pyrimidin-4-amine, triphenyl-synthesis, 3, 119... 

Molecular rotors with a dual emission band, such as DMABN or A/,A/-dimethyl-[4-(2-pyrimidin-4-yl-vinyl)-phenyl]-amine (DMA-2,4 38, Fig. 13) [64], allow to use the ratio between LE and TICT emission to eliminate instrument- and experiment-dependent factors analogous to (10). One example is the measurement of pH with the TICT probe p-A,A-dimethylaminobenzoic acid 39 [69]. The use of such an intensity ratio requires calibration with solvent gradients, and influences of solvent polarity may cause solvatochromic shifts and adversely influence the calibration. Probes with dual emission bands often have points in their emission spectra that are independent from the solvent properties, analogous to isosbestic points in absorption spectra. Emission at these wavelengths can be used as an internal calibration reference. 

Reaction of 4-chloro-6-fluoropyrido[3,4- pyrimidine 59 with [3-methyl-4-(pyridin-3-yloxy)phenyl]amine 60, followed by coupling the formed amine 61 with (3-azabicyclo[3.1.0]hex-6-yl)carbamic acid fi r7-butyl ester, afforded the substituted derivative 62 <2002EPP1249451>. Compound 59 was also reacted with 3-bromoaniline to give the 4-anilino derivative 63 that upon treatment with either methyl- or dimethylamine gave the corresponding 4,6-diamino derivatives 64 (Scheme 2) <1997W09726259, 1995W09519774>. 

Nielsen (81CS(18)135) prepared thieno[2,3-4]pyrimidin-4(3//)-ones in 43-90% yield by heating 2-acylaminothiophene-3-carboxylates (330) with phosphorus pentoxide, N,N -dimethylcyclohexylamine and an amine hydrochloride at 180 °C. By raising the temperature to 240 °C, thieno[2,3-4]pyrimidin-4-amines (331) were obtained in 27-34% yield (Scheme 92). Phenyl N,N -dimethylphosphorodiamidate [(MeNH)2P(0)OPh], a well-known reagent for the synthesis of 3-methyl-4-oxo-3,4-dihydroquinazolines (77S180), reacts with thiophene derivatives of type (330) to give 3-methylthieno[2,3-4]pyrimidin-4(3/f)-ones (78ACS(B)303). 

DIETHYL-0-(p-(METHYLSULFINYL)PHENYL) PHOSPHOROTHIOATE see FAQ800 0,0-DIETHYL-0-p-(METHYLSULFINYL)PHENYL THIOPHOSPHATE see FAQ800 N,N-DIETHYL-5-METHYL-(l,2,4)TRIAZOLO(l,5-a)PYRIMIDINE-7-AMINE see DI0200 DIETHYL-NICODYMIDE see DJS200... 

Trichloromethyl groups in the 2-position of pyrido[2,3-t/]pyrimidines can be replaced by oxygen functionalities as shown by the reactions of 4-amino-6-thiocyanato-5-phenyl-2-(trichloromethyl)pyrido[2,3-t/]pyrimidin-7(8//)-one (38) and 7-ethoxy-6-thiocyanato-5-phenyl-2-(trichloromethyl)pyrido[2,3- /]pyrimidin-4-amine with water or ethanol.128... 

A partial aromatization of hexahydropyrido[4,3-potassium hexacyanoferrate(III).531 Starting from the hydrochloride of8-benzylidene-6-methyl-4-phenyI-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2-thiol, after methylation of the sulfanyl group, the oxidation gives 8-benzylidene-2-(methylsuIfanyI)-6-methyl-4-phenyl-5,6,7,8-tetrahydropy-rido[4,3-d]pyrimidine. In a similar way, several 4-aryl-8-arylidene-6-methyl-3,4,5,6,7,8-hexahy-dropyrido[4,3-rf]pyrimidin-2-amines have been partially aromatized.513... 

The cyclization of 5-(Ar-benzoylcarbamimidoyl)-2-propylpyrimidin-4-amine (5) proceeds under dehydration leading to 2-phenyl-7-propylpyrimido[4,5-d]pyrimidin-4-amine (6) in a yield of 79% mp 239-241 °C (benzene).113... 

Narsaiah and co-workers employed the Dimroth rearrangement in their preparation of novel 4-substituted-amino-5-trifluormethyl-2,7-disubstituted pyrido[2,3-< pyrimidines and evaluated their potential as antibiotics against Gram-positive and Gram-negative bacteria. Treatment of iminoether 121 with methyl amine in ethanol at room temperature for 3 h gave rise to 7V-methyl-2-methyl-7-phenyl-5-(trifluoromethyl)pyrido[2,3-i/)pyrimidin-4-amine 122 in 84% yield. This compound showed significant... 

Pyrimidin-4-one, 2,5,6-triamino- N NMR, 3, 64 (78HCA2108) Pyrimido[4,5-d]pyridazin-5-amine, JV-benzyl-8-chloro-2-phenyl-pXa, UV, 3, 337 <76BSF(2)1549) Pyrimido[4,5-d]pyridazin-5-amine, JV-butyl-8-chloro-2-phenyl-... 

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