Phenyl acetamid

N-[2,4-Dimethyl-5-[[(trifluoromethyl)-sulfonyl]aniino] phenyl]acetamide] [53780-34-0]... 

Phenyl acetamides have a variety of pharmacological actions depending upon the nature of the amine-derived component. 

Chemical Name N-[4-[2-hydroxy-3-[(1-methylethyl)amino] propoxy) phenyl] acetamide... 

C 2HijF,N202 90357-51-0) see Bicalutamide 4 -cyano-3 -trifIuoromethylmethacrylanilide (CijHijFjNjO 90357-53-2) see Bicalutamide Af-[4-cyano-2-(trifluoromethyl)phenyl]acetamide (C (,H7F,N20 175277-96-0) see Mabuterol /V-(4-cyano-3-trifluoromethylphenyl)-3-(fluorophenyl-sulfanyl)-2-hydroxy-2-methylpropionamide (C,hH,4F4N202S 90356-78-8) see Bicalutamide 2-cyano-3-(3,4,5-trimethoxyphenyl)-2-propenoic acid ethyl ester... 

CjjH(,F2N20S 97963-62-7) see Pantoprazole sodium 4-(difluoromethoxy)-2-nitrobenzenamine (C7H(,F2N203, 97963-76-3) see Pantoprazole sodium A -[4-(difluoromethoxy)phenyl]acetamide (0)HyF2N02 22236-11-9) see Pantoprazole sodium 2-(difluoromethoxy)-l,l,l-trifiuoroethane (C3H3F5O 1885-48-9) see Isoflurane (5)-9,10-difluoro-3-methyI-7-oxo-2,3-dihydro-7/f-pyrb do[l,23-d ]-Iy4 benzoxazine-6-carboxylic acid (C,3Hyp2N04 100986-89-H) see Levofloxacin... 

A mixture of 0.33M of the acetophenone, 39 g of redistilled morpholine and 14.4 g sulfur is refluxed for 12 hours and the wrm solution poured into 175 ml hot ethanol. Cool to precipitate about 80% yield of the substituted phenylacetothiomorpholide (I). Mix about 50 g (I), 110 ml acetic acid, 16 ml sulfuric acid and 25 ml water and reflux 5 hours. Decant from the small amount of tar formed with stirring into 850 ml water. Filter, wash the precipitate with water and heat the precipitate with 225 ml 5% aqueous NaOH. Filter and acidify the filtrate with dilute HCI to give about 80% yield of the substituted phenylacetic acid (II). Mix about 21 g (II) and 25 g phosphorus pentachloride (caution), and after the initial reaction subsides, warm on the steam bath 10 minutes. Distill under reduced pressure to remove the POC1 and gradually add the residue to ice cold concentrated NH4OH. Filter, wash precipitate with water and air dry (can recrystallize from benzene with a little ethanol added) to get about 18 g (85%) of the substituted phenyl-acetamide (111). (Ill)... 

Dimethylurea, see Methyl isocyanate lYlV-Dimethylurea, see Aldicarb 2,2 -Dinitro-4,4 -azoxytoluene, see 2,4-Dinitrotoluene 2,4 -Dinitro-2, 4-azoxytoluene, see 2,4-Dinitrotoluene 4,4 -Dinitro-2,2 -azoxytoluene, see 2,4-Dinitrotoluene 6,6 -Dinitro-2,2 -azoxytoluene, see 2,4-Dinitrotoluene 4,4 -Dinitrobiphenyl, see Benzidine Dinitrocresols, see 2-Methylphenol iV-(2,6-Dinitro-3,4-dimethyl)phenyl acetamide, see... 

Finally there has been a growing interest in the development of selective leukotriene inhibitors. Bay Y 1015 (R-(-)-2-cycloheptyl-N-methylsulfonyl-(4-(2-quinolinyl-methoxy) phenyl)-acetamide) is a quinoline-type 5-lipoxygenase-activating protein inhibitor which was effective in inhibiting inflammation in a dextran sulfate model of mouse colitis [112]. Whether these compounds can also exert their anti-inflammatory action through inhibition of endothelial cell activation needs to be established. 

A GlaxoSmithKline patent reported a series of imidazo[5,l-/] [1,2,4]triazines to have activity against PLK-1 [276]. The most potent analogs, exemplified by compounds 114a,b, were active against PLK-1 in the submicromolar range and had anti-proliferative activity with IC50 values of 1 to 10 tiM. The preferred 2-substituents on the imidazotriazine core were the 3,4,5 trimethoxyaniline and M(4-amino-phenyl)acetamide, while the preferred 7-substituents were phenyl and meta-trifluoromethylphenyl. 

Atenolol Atenolol is 2-[4 [2-hydroxy-3-(Ao-propylamino)propoxy]phenyl]acetamide (12.1.7) [11-13]. 

When acetophenone oxime (1) is thermically treated with acidic solids in "dry media" under soft experimental conditions, two main products are obtained the rearrangement one acetanilide (N-phenyl acetamide) (2) obtained by Beckmann rearrangement with migration of the phenyl group, and the hydrolysis one acetophenone (3), obtained by the hydrolysis of the imino group (C=N) (eqn.2). 

PHENYL ACETAMIDE, N-HYDROXYL-N-PHENYL- (1795-83-1), 67, 187 ACETYLTRIMETHYLSILANE Silane, acetyltrimethyl (13411-48-8), 68, 25... 

N-Methyl-N-phenyl acetamide, 114 N-Methyl-N-phenylformamide, 113 Methyl phenyl glyoxalate, 327 N-Methyl-N-phenyl propionamide, 114 N-Methylpiperidone, 117 Methyl 2,3,4,6-tetra-0-acetyl-6-D-glucopyranoside, 85... 

The interruption of the hydrolysis of a nitrile at the amide stage can often be achieved in a preparative manner, as for example in the preparation of phenyl-acetamide (Expt 5.156), where the nitrile is dissolved in concentrated hydrochloric acid at 40 °C and subsequently poured into water. The use of hot polyphosphoric acid has also been recommended.166... 

So the N-[2-hydroxy-5-[4-(hydroxymethyl)-l,3,2-dithiarsolan-2-yl]phenyl] acetamide, melting point 163°-166°C is obtained. 

Ferrini and Marxer65 have recently shown that vinylene carbonate reacts with primary amides, in the presence of polyphosphoric acid, to yield 2-substituted oxazole derivatives. Yields are low (2-34%), and phenoxy- and phenyl-acetamide, p-methylbenzamide, and salicylamide do not give oxazole derivatives. Although the reaction has been interpreted according to Scheme 3, the nucleophilic attack of a nitrile molecule (from the amide dehydration), with a nitrilium salt as intermediate (Scheme 4), cannot be excluded.06... 

To a solution of -phenethyl-2-phenyl-acetamide 33 (5.50 g, 23.0 mmol) in THF (24 mL) stirred in an ice-bath under N2 for 1 h, was added BH3.DMS complex (4.4 mL, 46.0 mmol) and the reaction mixture was refluxed at 80 °C for 24 h. The reaction was allowed to come to room temperature followed by addition of MeOH/HCl (60.0 mL) the reaction was refluxed for an additional 1 h. The reaction was cooled to room temperature and the volatile components were removed under reduced pressure. The residue was taken up in H2O (100 mL) and basified to pH > 10. The reaction mixture was extracted with CH2CI2 (3 xl50 mL), washed with sat. NaHCCh (1 xl50 mL), washed with brine, dried over K2CO3 and filtered. The volatile components were removed under reduced pressure to give an oily liquid which was purified by vacuum distillation to give 4.74 g of 34 as an oily liquid in 91 % yield. 

A. H-[2,4-Bis(, 7>-diphenylimidazolidin-2-yl)-5-hydroxy-phenyl] acetamide. A 500-mL, 3-necked flask equipped with nitrogen inlet, mechanical stirrer, reflux condenser, and thermometer is charged with 88.8 g (0.2 mol) of l,l, 3,3 -tetraphenyl-2,2 -biimidazolidinylidene (Note 1) and 30.2 g (0.2 mol) of 3-acetami-dophenol (Note 2). The system is flushed with and maintained under nitrogen, and 100 mL of chlorobenzene (Note 3) is added. The suspension is stirred at 100°C for 6 hr (Note 4). 2-Propanol (250 mL) is added to the hot mixture, which is then allowed to cool to room temperature. A pale yellow solid precipitates which is filtered and washed with 200 mL of 2-propanol. Drying in vacuum affords 84.6-93.2 g (71-78%) of TV- [2,4-bis( 1,3-diphenylimi-dazolidin-2-yl)-5-hydroxyphenyl]acetamide, mp 254-256°C (Note 5). 

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