Phenothiazines Opiates

Dopamine inhibits prolactin synthesis. Drugs that inhibit dopamine synthesis or activity (e.g. antihypertensives, antidepressants, estrogen, phenothiazines, opiates), are the most common cause of hyperprolactinemia. Prolactin-secreting pituitary tumors sometimes are treated with bromocriptine, a dopamine agonist. 

Carbamazepine and tricyclic antidepressants, as well as phenothiazines, opiates, and barbiturates can cause hyponatremia, which would be additive with that produced by demeclocycline. 

Authors are designed row sensitive and selective test-systems for analysis of heavy metals, active chlorine, phenols, nitrates, nitrites, phosphate etc. for analysis of objects of an environment and for control of ions Ee contents in the technological solutions of KH PO, as well as for testing some of pharmacological psychotropic daigs alkaloids (including opiates), cannabis as well as pharmaceutical preparations of phenothiazines, barbiturates and 1,4-benzodiazepines series too. 

Phenothiazine-type antipsychotics will potentiate the CNS depressant action of many drugs including opiates and will potentiate the effects of general anaesthetic agents. All antipsychotics will antagonise the effect of L-dopa in Parkinson s disease, making management of this difficult where it co-occurs with psychosis. 

Other nervous system depressants that could trigger a GHB overdose reaction are benzodiazepines (mild tranquilizers such as Valium and Xanax), phenothiazines (potent tranquilizers like Thorazine and Stellazine), various painkillers (barbiturates and opiates), anticonvulsants (Dilantin and phenobarbital), and even many over-the-counter allergy and sleep remedies. 

Among the many toxicants that cause convulsions are chlorinated hydrocarbons, amphetamines, lead, organophosphates, and strychnine. There are several levels of coma, the term used to describe a lowered level of consciousness. At level 0, the subject may be awakened and will respond to questions. At level 1, withdrawal from painful stimuli is observed and all reflexes function. A subject at level 2 does not withdraw from painful stimuli, although most reflexes still function. Levels 3 and 4 are characterized by the absence of reflexes at level 4, respiratory action is depressed and the cardiovascular system fails. Among the many toxicants that cause coma are narcotic analgesics, alcohols, organophosphates, carbamates, lead, hydrocarbons, hydrogen sulfide, benzodiazepines, tricyclic antidepressants, isoniazid, phenothiazines, and opiates. 

Phenothiazines and related drugs, e.g., chlorpromazine (Largactil/ Thorazine). Some tricyclic antidepressants, e.g., amitriptyline Dibenzodiazepine derivatives and thienobenzodiazepines, e.g., clozapine, olanzapine Benzodiazepines, e.g., diazepam (Valium), nitrezepam (Librium) and lorazepam Barbiturates Opiates... 

All the major oxidative mechanisms can be illustrated by considering the metabolism of the barbiturates, benzodiazepines, amphetamines, tricyclic antidepressants, phenothiazines, and opiates. 

Dopamine antagonists (e.g., phenothiazines, haloperidol, methyidopa) Opiates Estrogens H2-antagonists (e.g., cimetidine) MAO inhibitors Dopamine agonists (e.g., levodopa, bromocriptine, pergolide, cabergoline) ... 

Those agents that interact with calcium channels but have another primary site of action include agents acting on sodium channels (local anesthetics and phenytoin), catecholamine receptors (benextramine, nicergoline, phenoxy-benzamine, phenothiazines, pimozide, propranolol, and yohimbine derivatives), benzodiazepine receptors (diazepam and flurazepam), opiate receptors (loperamide and flu-peramide), and cyclic nucleotide phosphodiesterases (amrinone, cromoglycate, and papaverine), as well as barbiturates, cyproheptadine, indomethacin, and reserpine. 

Anticholinergics Antihistamines Phenothiazines Tricyclic antidepressants Opiates... 

Sympatholytic syndrome. Blood pressure and pulse rate are both decreased (peripheral alpha blockers may cause hypotension with reflex tachycardia). The pupils are small, often of pinpoint size. Peristalsis is often decreased. (Examples centrally acting alpha-2 agonists [clonidine and methyidopa], opiates, and phenothiazines.)... 

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