Sympatholytic syndrome

Sympatholytic syndrome. Blood pressure and pulse rate are both decreased (peripheral alpha blockers may cause hypotension with reflex tachycardia). The pupils are small, often of pinpoint size. Peristalsis is often decreased. (Examples centrally acting alpha-2 agonists [clonidine and methyidopa], opiates, and phenothiazines.)... 

Overall, the frequency of adverse effects produced by guanabenz is similar to that produced by cionidine and the other Q2-adrenergic agonists, but the incidence is lower. As with the other centrally active sympatholytics (e.g., cionidine), abrupt withdrawal of guanabenz may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe. 

Overall, although the frequency of troublesome adverse effects produced by guanfacine is similar to that produced by clonidine and the other centrally acting sympatholytics, their incidence and severity are lower with guanfacine. Unlike clonidine, abrupt discontinuation of guanfacine rarely results in rebound hypertension. When a withdrawal syndrome has occurred, its onset was slower and its symptoms less severe than the syndrome observed with clonidine. 

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See also in sourсe #XX -- [ , ]

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