Phenformin

Chemical Name N-(2-Phenylethyl)imidodicarbonimidic diamide Common Name Phenethyidiguanide Structural Formula  

Chemical Abstracts Registry No. 114-86-3 Trade Name Manufacturer 

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Phenformin. Phenformin hydrochloride [834-28-6] (1-phenethylbiguanide, A/-(2-phenylethyl)imidodicarbonimidic diamide), is a white to off-white odorless crystalline power having a bitter taste. The melting point is 175—178°C. It is freely soluble in water and alcohol, and practically insoluble in chloroform, ether, and hexane. Its pH in solution is 6.0—7.0. 

Yet another example of a so-called pharmacophoric group is the biguanide functionality, a grouping associated with oral antidiabetic activity (see the section on sulfonylureas for a fuller discussion of this activity). Condensation of 2-phenethylamine with dicyanamide affords directly the orally active hypoglycemic agent phenformin (88). ... 

A class of drug derived from guanidine, including metformin and phenformin. Metformin is currently widely used in humans for the treatment of type 2 diabetes. Phenformin was formerly also widely used but was withdrawn because of problems with lactic acidosis. 

Phenazopyridine hydrochloride, 3,465 Phenelzine sulfate, 2,383 Phenformin hydrochloride, 4, 319 5,429 Phenobarbital, 7, 359... 

Phenformin, antiaging agent, 2 813 Phenhydan, molecular formula and structure, 5 9 It... 

Tolbutamide and phenformin, oral antidiabetic agents, have been analyzed directly on /iBondapak C,s using methanol-water which contained l-heptancsulfonic acid in addition for the phenformin determination (263). 

II.f.2.3. Biguanides. The two important drugs of this class are metformin and phenformin. Phen-formin is now rarely used due to its high risk of lactic acidosis and in many countries it is even taken... 

Compounds containing guanidine group arginine, creatinine, bethanidine, streptomycin, phenformin, metformin, chlorhexidine. 

Adverse gastrointestinal symptoms (nausea, vomiting, anorexia, metallic taste, abdominal discomfort, and diarrhea) occur in up to 20% of individuals taking metformin this can be minimized by starting at a low dose and slowly titrating the dose upward with food. Like phenformin, metformin can cause lactic acidosis, but its occurrence is rare except when renal failure, hypoxemia, or severe congestive heart failure is present or when coadministered with alcohol. Metformin is also contraindicated in persons with hepatic dysfunction, but it appears to be safe for use in the hepatic steatosis that often occurs with fatty infiltration of the liver in poorly controlled type II diabetics. 

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