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Pharmacon

Miller, K.J. Anderholm, D.C. and Ames, M.M. Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations. Biochem Pharmacon>5 mi- lA2, 1986. [Pg.355]

Disintegration official in Brit Pharmacon and USP PMA Tablet Committee proposes 1% solubility threshold USP and NF Joint Panel on Physiological Availability chooses dissolution as a test chooses an apparatus Initial 12 monograph standards official Variables assessment more laboratories, three Collaborative Studies by PMA and Acad. Pharm. Sci First calibrator tablets pressed First Case default proposed to USP... [Pg.9]

Nomenclature. The terms active agent and pharmacon designate substances that are capable of modifying life processes irrespective of whether the effects elicited may benefit or harm the organisms concerned. By this definition, a toxin is also a pharmacon. Taken in a narrower sense, a pharmacon means a substance that is used for therapeutic purposes. An unequivocal term for such a substance is medicinal drug. [Pg.333]

When tablet formulations are made, usually different quality criteria have to be met, e.g., a high crushing strength, a low disintegration time, a pre-set dissolution profile. A tablet consists normally of the pharmacon (the pharmacologically active compound the drug) and excipients. Hence, a tablet can be made with different relative amounts of excipients (a mixture composition) and this creates room for optimizing a tablet... [Pg.2]

Figure 6. Schematic representation of the pharmacophore-pharmacon complex. Figure 6. Schematic representation of the pharmacophore-pharmacon complex.
Ariens, E. J., Rodrigues de Miranda, J.F., Simonis, A. M., The pharmacon-recep-tor-effector concept a basis for understanding the transmission of information in biological systems. In The Receptors, O Brien, R. D. (ed.). Plenum Press, New York, 1979, pp. 33-91. [Pg.16]

Definition 1 (Paul Ehrlich, 1909) A pharmacophore is a molecular framework that carries (phoros) the essential features responsible for a drug s (pharmacon) biological activity [1]. [Pg.325]

International classification C08B37/00, C12N9/96, C12N11/10 The invention relates to an auxiliary substance to accompany an active substance, such as a pharmacon. The auxiliary substance has a stabilizing action and a positive influence on the bioavailability of the active substance within pharmaceutical preparations. The auxiliary substance is based on a fructan (inulin of degree of polymerization (DP) over 6), obtained from Jerusalem artichoke or other sources. [Pg.423]

Tiiry G, Szabo GT, Vabrik R, Rusznak I, Nyitrai Z, Vig A. Deceleration of light-induced changes of selected pharmacons by means of Ught screerUng films. J Photochem Photo-biol A Ghem 1997 111(1-3) 171-179. [Pg.320]

Pharmacons (glucocorticoids, contraceptives, antimetabolites, chelate formers)... [Pg.51]

Protein content of nutrition 2. Pharmacons 3. Chemicals 4. Alcohol 5. Constituents of tobacco smoke 6. Heavy metals 7. Pregnancy 8. Diseases, etc. 1. Genetics 2. Gender 3. Age... [Pg.54]

Owing to the greater sensitivity of PBC patients to pharmaceutical preparations, different pharmacons, e. g. phenothiazines, contraceptives, oestrogens and anabolic steroids, can reinforce cholestasis and the clinical symptoms, thus aggravating the course of disease. Gallstones are frequently detectable (35-40%) as a rule, they are pigment gallstones. Administration of clofibrate is con-... [Pg.647]

Foreign substances Given an individual predisposition, chemicals or pharmacons (505) may trigger the syndrome of vanishing bile ducts. Nmnerous drugs can be included in this category, (s. tab. 29.3)... [Pg.665]

The prognosis of cirrhosis caused by toxins (alcohol or medicament abuse, chemical agents, iron storage, etc.) is usually markedly improved by eliminating the causal noxa. Recognition and treatment of secondary immuno-reactions, which may occur concomitantly, are also important. As a result of such reactions, the prognos-tically favourable effect of abstention (e.g. alcohol, pharmacons) may be reduced unless adequate countermeasures with drugs are possible. [Pg.740]

Therapeutic status The name and dosage of the pharmacons used in the meantime the name and date of any medicine discontinued or newly prescribed side effects/intolerances observed, if any (all relevant details concerning the remedies are recorded, which facilitates interim repeat prescriptions). [Pg.744]

Iain J. McGUveray / McGilveray Pharmacon, Inc., Nepean, Ontario, Canada... [Pg.4321]

D) Induction of irreversible changes in the biological object by a reversible interaction with the pharmacon, such that the effect continues even after the drug is totally eliminated. An example is abnormal embryonic development due to early intrauterine exposure to hormones. [Pg.3]

E) Induction of irreversible changes in the structure of essential cell constituents as a result of exposure to the pharmacon. This implies a certain degree of chemical denaturation of these cell constituents indicated as chemical lesions 3,4 24-. ... [Pg.3]

See other pages where Pharmacon is mentioned: [Pg.12]    [Pg.14]    [Pg.3]    [Pg.16]    [Pg.232]    [Pg.131]    [Pg.423]    [Pg.111]    [Pg.60]    [Pg.253]    [Pg.96]    [Pg.51]    [Pg.529]    [Pg.543]    [Pg.547]    [Pg.608]    [Pg.625]    [Pg.638]    [Pg.638]    [Pg.652]    [Pg.653]    [Pg.719]    [Pg.3027]    [Pg.4312]    [Pg.3]    [Pg.3]    [Pg.4]    [Pg.4]    [Pg.4]    [Pg.5]   
See also in sourсe #XX -- [ Pg.6 ]



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Pharmacon Metabolism by Molecular Manipulation

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