Pharmacokinetics aspects

Pharmacodynamics is the study of dmg action primarily in terms of dmg stmcture, site of action, and the biochemical and physiological consequences of the dmg action. The availabiUty of a dmg at its site of action is deterrnined by several processes (Fig. 1), including absorption, metaboHsm, distribution, and excretion. These processes constitute the pharmacokinetic aspects of dmg action. The onset, intensity, and duration of dmg action are deterrnined by these factors as well as by the avadabihty of the dmg at its receptor site(s) and the events initiated by receptor activation (see Drug delivery). 

Tang, L., Persky, A.M., Hochhaus, G., and Meibohm, B. 2004. Pharmacokinetic aspects of biotechnology products. Journal of Pharmaceutical Sciences 93(9), 2184-2204. 

Slish, J.C. et al. 2006. Update on the pharmacokinetic aspects of antiretroviral agents Implications in therapeutic drug monitoring. Curr Pharm Des. 12 1129. 

Compounds of the same therapeutic class may profoundly differ as to QT prolonging potential in addition, the assessment of the proarrhythmic risk must take into account pharmacokinetic aspects including metabolism, since a very low baseline proarrhythmic risk may become clinically important in case of drug interactions leading to higher than expected plasma levels. 

Pharmacokinetic Aspects of Antisense Oligodeoxynucleotides and Renal Distribution... 

The effectiveness of drug targeting should be evaluated by taking into account not only pharmacokinetic aspects, but also the pharmacodynamic aspects. The latter include the concentration-effect relationship in the target tissue and at the sites where toxicity may occur [7,12]. The therapeutic effect of the drug and its toxic effect may be different with regard to their mechanisms, and hence their concentration-effect relationship may also be different, both qualitatively (different PD models) and quantitatively (different model parameters). 

Dickins, M., Galetin, A. and Proctor, N. (2007) Modelling and simulation of pharmacokinetic aspects of cytochrome P450-based metabolic dmd-drug interactions, in Comprehensive Medicinal Chemistry II, vol. 5 (eds J.B. Taylor and D.J. Triggle), Elsevier Ltd, Oxford,... 

Camilleri M, Bueno L, de Ponti E, Fioramonti J, Lydi-ard RB, Tack J. Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders. Gastroenterology 2006 130 1421-34. 

Knudsen P. Chemotherapy with neuroleptics. Clinical and pharmacokinetic aspects with a particular view to depot preparations. Acta Psychiatr Scand Supp11985 322(72) 51-75. 

Vollmer, K.O. [Pharmacokinetic aspects of the Valoron-N principle. Balanced pharmacokinetics of nortilidine and naloxone], Fortschr. Med. 1988, 106, 593-596. 

Panchagnula, R., and Agrawal, S. (2004). Biopharmaceutic and pharmacokinetic aspects of variable bioavailability of rifampicin. Int. J. Pharm. 271 1-4. 

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