Pharmacology pharmacokinetics

Howell A, DeFriend DJ, Robertson JF, Blarney RW, Anderson L, Anderson E, Sutcliffe FA, Walton P (1996) Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer. Br J Cancer 74 300-308... 

V. In vivo pharmacology pharmacokinetics pharmacology screening Animal Determine pharmacokinetic profile of ohgos, i.e., absorption, distribution, metabolism, and elimination Determine pharmacological effects of ohgos on host tissues other than desired effects... 

Artru A A 1990 Hypocapnia and diazepam reverse and midazolam or fentanyl attenuates ketamine induced Increase of cerebral blood volume and/or cerebrospinal fluid pressure. In Domino E F (ed) Status of ketamine in anesthesiology. NPP Books, Ann Arbor, Ml, p. 119 Aurich C, Aurich J E, Klug E 1993 Naloxone affects gastrointestinal functions and behaviour in horses. Deutsche Tierarztiiche Wochenschrift 100 314-315 Ballard S, Shults T, Kownacki A A et al 1982 The pharmacokinetics, pharmacological responses and behavioral effects of acepromazine in the horse. 

Tucker, G.I. Lennard, M.S. (1990) Enantiomer specific pharmacokinetics. Pharmacology and Therapeutics, 45, 309-329. 

In conclusion, phosphorothioate oligonucleotides may interact with a wide range of proteins through several types of mechanisms. These interactions may influence the pharmacokinetic, pharmacologic, and toxicologic properties of these molecules. They may also complicate studies on the mechanism of action of these drugs, and may obscure an antisense activity. For example, phosphorothio-... 

Metabolism of drugs by the skin is gaining interest because of its pharmacokinetic, pharmacological therapeutic, and toxicological Implications The metabohc capacity of the skin can be exploited in the field of dermal drug... 

Thron, C.D. Linearity and superposition in pharmacokinetics. Pharmacology Reviews 1974 26 3-31. 

Series of articles on pharmacokinetics, pharmacology and efficacy in insomnia Sleep. l0, Suppl 1, 1-79 (1987). Review of pharmacology and therapeutic efficacy K. L. 

Such factors may change not only the kinetics of an enzyme reaction but also the whole pattern of metabolism, thereby altering the bioavailability, pharmacokinetics, pharmacological activity, or toxicity of a xenobiotic. Species differences in response to xenobiotics must be considered during the extrapolation of pharmacological and toxicological data from experiments in animals to humans. The primary factors in these differences probably are the rate and pattern of drug and xenobiotic metabolism in the various species. 

The pharmacokinetics, pharmacology, chemotherapeutic effects, toxicity, chromosome aberatlons and mutagenic potency of adriamycin were reported. 105-109 Adriamycin is useful for acute lymphoblastic and chronic myelogenous leukemias, transitional cell carcinoma, llposarcoma, squamous cell carcinoma, and adenocarcinoma of the breast. It is less toxic than daunorubicin. Resistance to daunorubicin is due to changes in the cellular membrane.no Both antibiotics possess Immunosuppressive properties.HI... 

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