Pharmaceuticals advantages

Fugioka, ., Kurosaki, Y., Sato, S., Noguchi, T., andYamahira, Y. 1983. Biopharmaceutical study of inclusion complexes. I. Pharmaceutical advantages of cyclodextrin complexes of bencyclane fuffibeate. 

In a demonstration of the pharmaceutical advantage that can be realized through the use of a cocrystal form of a substance, it was shown that the 1 1 cocrystal of caffeine and methyl gallate exhibited significantly improved powder compaction properties [64], The compression characteristics of the cocrystal were reported to be excellent over the entire pressure range studied, with the tablet tensile strength of the cocrystal being twice that of caffeine at pressures less than 200 MPa. The superior compaction properties of the cocrystal product were attributed to the presence of slip planes in crystal structure. 

Microemulsions are defined as isotropic, transparent, and thermodynamically stable (in contrast to conventional emulsions) mixtures of a hydrophobic phase (lipid), a hydrophilic phase (often water), a surfactant, and in many cases a co-surfactant. From a lipid formulation perspective, microemulsions are generally regarded as the ultimate extension of the decreased particle size/increased surface area mantra, because emulsion particle sizes are usually less than 50 nm. Microemulsions also have additional pharmaceutical advantages in terms of their solubilizing capacity [54, 55], thermodynamic stability, and capacity for stable, infinite dilution. 

Piperazine Estrone Sulfate (3-Sui.FOxv-E iTiu-l,3,5(l0)-TRIEN-17-ONF. Piperazine Salt), USP. All the estrone 3-.sulfate salts have the obvious pharmaceutical advantage of increased water solubility and better oral absorption. Acids convert the salts to the free 3-sulfate esters and cause some hydrolysis of the ester. This does not seem to affect absorption adversely, but precipitation of the free sulfate esters in acidic pharmaceutical preparations should be avoided. The dibasic piperazine molecule acts as a buffer, giving it somewhat greater stability. 

Peptide mimetics have been defined as moiecuies that mimic the action of peptides, have no peptide bonds (i.e., no amide bonds between amino acids), and a moiecuiar weight of less than 700 Daltons. In comparison with peptide drugs, peptide mimetics have numerous pharmaceutical advantages. Foremost among these are increased bloavallablllty and Increased duration of action. The majority of known peptide mimetics have been discovered by random screening techniques however, this process is costly, labor intensive, and unpredictable. 

Quick-breaking foams consist of a miscible solvent system such ethanol (qv) [64-17-5] and water, and a surfactant that is soluble in one of the solvents but not in both. These foams are advantageous for topical appHcation of pharmaceuticals because, once the foam hits the affected area, the foam coUapses, deUvering the product to the wound without further injury from mechanical dispersion. This method is especially usehil for treatment of bums. Some personal products such as nail poHsh remover and after-shave lotion have also been formulated as quick-breaking foams. 

Since the development of the Spansule brand (Smith Kline Beech am) of coated beads and granules in the late 1960s, various dmg product technologies have been developed and patented to achieve extended durations of therapeutic effects. Each of these does so by various mechanisms of control of dmg release from adrninistered dosage forms. Each method has its advantages and disadvantages, a discussion of which is available in the pharmaceutical hterature (see Drug delivery systems) (21). 

The principal industrial appHcation for isobutyl alcohol is as a direct solvent replacement for 1-butanol. It is also used as a process solvent in the flavor and fragrance, pharmaceutical, and pesticide industries. The maximum employment of isobutyl alcohol was in the mid-1980s when it had a distinct price advantage over 1-butanol (10). More recently, however, with increased demand for other value added derivatives of isobutyraldehyde, the price differential between isobutyl and -butyl alcohols has diminished resulting in a switching back by some consumers to 1-butanol. 

A refined grade of MTBE is used ia the solvents and pharmaceutical iadustries. The main advantage over other ethers is its uniquely stable stmctural framework that contains no secondary or tertiary hydrogen atoms, which makes it very resistive to oxidation and peroxide formation. In addition, its higher autoignition temperature and narrower flammabihty range also make it relatively safer to use compared to other ethers (see Table 3). 

Batch Crystallization Batch crystalhzation has been practiced longer than any other form of ciystaUization in both atmospheric tanks, which are either static or agitated, as well as in vacuum or pressure vessels. It is still widely practiced in the pharmaceutical and fine chemical industry or in those applications where the capacity is veiy small. The integrity of the batch with respect to composition and history can be maintained easily and the inventoiy management is more precise than with continuous processes. Batch ciystalhzers can be left unattended (overnight) if necessary and this is an important advantage for many small producers. 

Pnor to 1975, discussions of fluonnatcd pharmaceuticals focused mainly on anti-mflammatory steroids, antipsychotic phenothiazines, and 5-fluorouraciI and Its derivatives as anticancer agents [/ 2] Dunng the past 25 years, and especially in the last decade, tluonnated dmgs have been marketed for the treatment of a wide variety of diseases This section will focus on those presently marketed drugs where the presence of fluonne has produced significant therapeuhc advantages... 

As a matter of fact, the main advantage in comparison with HPLC is the reduction of solvent consumption, which is limited to the organic modifiers, and that will be nonexistent when no modifier is used. Usually, one of the drawbacks of HPLC applied at large scale is that the product must be recovered from dilute solution and the solvent recycled in order to make the process less expensive. In that sense, SFC can be advantageous because it requires fewer manipulations of the sample after the chromatographic process. This facilitates recovery of the products after the separation. Although SFC is usually superior to HPLC with respect to enantioselectivity, efficiency and time of analysis [136], its use is limited to compounds which are soluble in nonpolar solvents (carbon dioxide, CO,). This represents a major drawback, as many of the chemical and pharmaceutical products of interest are relatively polar. 

Although in many cases an enantiopure drug can be safer than the racemate, the advantages are clear. The final formulation of the drug product could be reduced inhalf, potential side effects could be minimized, and the resulting pharmokinetic and pharmacodynamic studies could clearly determine the efficacy of the active pharmaceutical ingredient (API) [21]. 

Insulin is one of the important pharmaceutical products produced commercially by genetically engineered bactera. Before this development, commercial insulin was isolated from animal pancreatic tissue. Microbial insulin has been available since 1982. The human insulin gene is introduced into a bacterium like E. coli. Two of the major advantages of insulin production by microorganisms are that the resultant insulin is chemically identical to human insulin, and it can be produced in unlimited quantities. 

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