Methyl gallate

Although the metabolism of vanillate generally involves de-O-methylation to 3,4-dihy-droxybenzoate followed by intradiol ring hssion, in Acinetobacter Iwoffii vanillate is hydroxylated to 3-0-methyl gallate, which produces pyruvate and oxalacetate in reactions that have already been noted (Sze and Dagley 1987). 

Catechin, epi-gallo LP" Catechin-3-0-(3 -0-methyl) -gallate, epi(-) Lf 0.08% Catechin-3-0-(3-0-methyl)-gallate,... 

In a demonstration of the pharmaceutical advantage that can be realized through the use of a cocrystal form of a substance, it was shown that the 1 1 cocrystal of caffeine and methyl gallate exhibited significantly improved powder compaction properties [64], The compression characteristics of the cocrystal were reported to be excellent over the entire pressure range studied, with the tablet tensile strength of the cocrystal being twice that of caffeine at pressures less than 200 MPa. The superior compaction properties of the cocrystal product were attributed to the presence of slip planes in crystal structure. 

C.C. Sun, H. Hou, Improving mechanical properties of caffeine and methyl gallate crystals by cocrystallization, Cryst. Growth Des. 8 (2008) 1575-1579. 

Small molecules can undergo self-organization into a wide variety of orientations besides nanotubes. For example, in 2003, Percec designed a system of self-assembled dendritic benzamides based on methyl gallate and trimethoxyben-zene that exhibited a liquid crystalline phase both as monomers and as polymers (Fig. 7.7) [52],... 

Methyl gallate campechianum (Eabaceae) [leal J Phyllanthus urinaria relaxant] Opens Ca2+-K+CH (ATP-K+... 

Methyl gallate (= 3,4,5-trihydroxybenzoic acid methyl ester) (phenolic ester)... 

Thoma and Klimek (115) also found that the natural food colorant curcumin as well as Fast Yellow, chrysoine, apocarotinol, and, cochineal Red A photostabi-lized solutions of nifedipine and nitrofurazone. They also found that vanillin and methyl gallate could stabilize solutions of dihydroergotamine. These authors also found that furosemide was stabilized by the addition of vanillin, haloperidol by benzyl alcohol, and vanillin and thiothixene by quinosol and vanillin. 

Methyl ester, CtH Op methyl gallate, gallicin. Mono-clinic prisms from methanol, often hydtated or solvated. When dry, mp 202. Sol in hot water, alcohol, methanol, ethar. 

Beilstein Handbook Reference) AI3-00861 Benzoic acid, 3,4,5-trihydroxy-, methyl ester BRN 2113180 CCRIS 5567 EINECS 202-741-7 Gallic acid methyl ester Methyl 3,4,5-trihydroxybenzoate Methyl gallate Methylgallate NSC 363001. Used by ophthalmologists as an antiseptic in conjunctivifis. Crystals mp = 202 soluble in hot H2O, EtOH, MeOH, Et20. 

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