Pharmaceutical technology coatings

This book is a companion volume to Pharmaceutical Technology Controlled Drug Release, Volume 1, edited by M.H.Rubinstein and published in 1987. It focused on the different types of polymeric materials used in controlled release. This book extends these concepts to include drug properties, design and optimization, coating, the effect of food and pharmacokinetics. It also reflects the growing interest in biodegradable polymers in oral and topical formulations and the use of sterile implants. 

Fig. 10. Pellets coated with ethyl cellulose in an organic solution. (Reprinted with permission of Pharmaceutical Technology, copyright 1985.)...

K. Lehmann, B. Brogmann, Tablet Coating, Encyclopedia of Pharmaceutical Technology, Volume 74 355-384 (1996). 

Radebaugh, G. W. (1990-1996), Film coating and film-forming materials Evaluation, in Swarbrick, J., and Boylan, J. C., Eds., Encyclopedia of Pharmaceutical Technology, Vol. 6, Marcel Dekker, New York. 

Murthy, K.S. Enders, N.A. Mahjour, M. Fawzi, M.B. A comparative evaluation of aqueous enteric polymers in capsule coatings. Pharm. Tech. 1986, 10 (Oct), 36 6. Thoma, K. Oschmann, R. Investigations of the permeability of enteric coatings, part 5 pharmaceutical-technological and analytical studies of enteric-coated preparations. Pharmazie 1991, 46, 278-282. 

Factors Affecting Drug Release from Sustained-Release Film-Coated Pellets Using Acrylic Aqueous Dispersions, 6th International Conference on Pharmaceutical Technology, June, 2, 1992. 

Most of the samples being investigated by SEM in the field of pharmaceutical technology are powders prepared by different methods, granules, pellets, tablets, and films from coated tablets. The sample preparation of bulk materials includes the following steps ... 

Newton JM. Extruders and extrusion. In Swarbrick J. Boy Ian JC. eds. Encyclopaedia of Pharmaceutical Technology. Vol. 2, 2nd cd. New York Marcel Dekkcr, 2002 1226-36. Fitzpatrick S, Taylor S. Booth SW, ct al. The development of a stable, coated pellet formulation of a water sensitive drug, a ca.sc study Development of a stable core formulation. Pharm Dev Tech 2006 11 521-8. 

Lehmann K, Brogmann B. Tablet coating. In Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. New York Marcel Dekker. Inc., 1996. 

J. Swarbrick and J. C. Boylan, Air suspension coating , in Encyclopedia of Pharmaceutical Technology, Vol. 1, Absorption of Drugs to Bioavailability of Drugs and Bioequivalence, Marcel Dekker, Inc., New York, USA, and Basel, Switzerland, 1988, pp. 189-215. 

Polymers and biopolymers can not only be active substances but also preparation bases (e.g. ointment and suppository bases), stabilizing additives in emulsions and suspensions, fillers, binders, disintegrants, lubricants, and gli-dants in tablet preparation. Coating polymers lead us to a major field of modern pharmaceutical technology, which is controlling the release or dissolution of active substances. 

Part IV includes applications of various biopolymers such as seed coating to protect against biotic stress, biosorbent for the organic pollutant, pharmaceutical technology, drug delivery, and gene therapy. 

Silicon oxide film (SiOx) is an interesting material in the field of the food and pharmaceutical technologies as well as the microelectronics technology. SiOx film possesses a high gas barrier property besides high thermal stability and high electrical insulation. Therefore, SiOx-coated polyester (PET) film is a possible material used for packing to protect foods or medicines from the deterioration by oxidation. 

Since the development of the Spansule brand (Smith Kline Beech am) of coated beads and granules in the late 1960s, various dmg product technologies have been developed and patented to achieve extended durations of therapeutic effects. Each of these does so by various mechanisms of control of dmg release from adrninistered dosage forms. Each method has its advantages and disadvantages, a discussion of which is available in the pharmaceutical hterature (see Drug delivery systems) (21). 

Delivery systems that respond to changes in pH have been known to the pharmaceutical industry for more than a century. The pH-sensitive enteric coating is probably the oldest controUed-release technology. Unna introduced an enteric tablet coating based on keratin in 1884 (108). Enteric coatings are used primarily to protect the gastric mucosa from local irritation or to ensure that tablets do not dissolve until they reach the intestine. 

Coating/encapsulation technologies for pharmaceuticals, textile apparel, and manufactured parts such as in the automotive industry... 

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