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Pharmaceutical biotechnology, protein

Additional future innovations likely to impact upon pharmaceutical biotechnology include the development of alternative product production systems, alternative methods of delivery and the development of engineered cell-based therapies, particularly stem cell therapy. As mentioned previously, protein-based biotechnology products produced to date are produced in either microbial... [Pg.10]

Almost all products of modern pharmaceutical biotechnology, be they on the market or likely to gain approval in the short to intermediate term, are protein based. As such, an understanding of protein structure is central to this topic. A comprehensive treatment of the subject would easily constitute a book on its own, and many such publications are available. The aim of this chapter is to provide a basic overview of the subject in order to equip the reader with a knowledge of protein science sufficient to understand relevant concepts outlined in the remaining chapters of this book. The interested reader is also referred to the Further reading section, which lists several excellent specialist publications in the field. Much additional information may also be sourced via the web sites mentioned within the chapter. [Pg.13]

Wishart, D. 2005. NMR spectroscopy and protein structure determination applications to drug discovery and development. Current Pharmaceutical Biotechnology 6(2), 105-120. [Pg.35]

Saunders LM, Hendren RW. Protein Delivery Physical Systems, Pharmaceutical Biotechnology, Vol. 10, Plenum Press, New York, 1997. [Pg.175]

Kenney. W.C., Arakawa. T. (1997). Biophysical and biochemical analyses of recombinant proteins Structure and analyses of proteins. In Crommelin D.J.A., Sindelar R.D., eds., Pharmaceutical Biotechnology. Harwood Academic Publishers, Amsterdam, 27-51. [Pg.176]

Braeckman, R. 1997. Pharmacokinetics and pharmacodynamics of peptide and protein dmgs. In D. Crommelin, and R. Sindelar (Eds.), Pharmaceutical Biotechnology. Harwood Academic Publishers, Amsterdam, pp. 101-122. [Pg.40]

Yamamoto, O. (1992), Effect of radiation on protein stability, in Ahern,T. J., and Manning, M. C. Eds., Pharmaceutical Biotechnology, Vol. 2, Stability of Protein Pharmaceuticals. Part A Chemical and Physical Pathways of Protein Degradation, Plenum, New York. [Pg.31]

Beatrice, M. (2002), Regulatory considerations in the development of protein Pharmaceuticals, in Nail, S., and Akers, M., Eds., Development and Manufacture of Protein Pharmaceuticals, Pharmaceutical Biotechnology, Vol. 14, Kluwer Academic/Plenum, New York, pp. 405 157. [Pg.57]

Audus, K.L. Raub, T.J. Biological barriers to protein delivery. In Pharmaceutical Biotechnology Plenum Press New York, 1993 4. [Pg.2753]

Hofmann, F.K. Scaleup of production and purification of cell expressed proteins. In Pharmaceutical Biotechnology, Fundamentals and Essentials Klegerman, M.E., Groves, M.J., Eds. Interpharm Press Buffalo Grove, IL, 1992 138-164. [Pg.3907]

Nail, Steven L., and Michael J. Akers. Development and Manufacture of Protein Pharmaceuticals. Vol. 14 of Pharmaceutical Biotechnology. New York Kluwer Academic/ Plenum Publishers, 2002. [Pg.302]

Carpenter JF, Manning MC, eds. Rational Design of Stable Protein Formulations Theory and Practice (Pharmaceutical Biotechnology). New York Plenum Press, 2003. [Pg.460]

Ferraiolo B L, Mohler M A, Gloff C A (1992). Protein pharmacokinetics and metabolism, in Pharmaceutical Biotechnology, vol. 1. Plenum Press, New York, p. 136. [Pg.810]

Arakawa T, Philo JS. Biophysical and biochemical analyses of recombinant proteins. In Pharmaceutical Biotechnology An Introduction for Pharmacists and Pharmaceutical Scientists, 2nd Ed. London Taylor and Francis, 2002 25-52. [Pg.271]

Reddy I. Protein and peptide drug delivery. In Zito SW, ed. Pharmaceutical Biotechnology A Programmed Text. Lancaster, PA Technomic Publishing, 1997 159-182. [Pg.273]

In fact, pharmaceutical biotechnology is one of the key industries today. Recombinant DNA technologies have entered drug discovery and all fields in the development and manufacture of therapeutic proteins and nucleotides. Biotechnology has a major impact on pharmaceutical industry because recent advances in recombinant protein chemistry, vaccine production, and diagnostics have and will revolutionize the... [Pg.4]


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