Petroleum hydrocarbons mixed function oxidase

Further Studies on the Effect of Petroleum Hydrocarbons on Mixed-Function Oxidases in Marine Organisms... 

Exposure of various invertebrate species to high concentrations of petroleum did not induce mixed function oxidase activity. Enzyme activity was stimulated, however, in a number of fish tissues by petroleum. Different permutations can be addressed as to the significance of basal or induced levels of mixed function oxidases and hydrocarbon toxicity. AHH may have a physiological role in enhancing hydrocarbon clearance but may also increase the mutagenic-carcinogenic potential of hydrocarbons. Both of these concepts have been demonstrated in studies with fish (29,30). Induced AHH levels may permit a more rapid oxidative transformation with concomitant "disappearance" of parent hydrocarbons, but potentially toxic metabolites could be retained in tissues for longer periods (31). It is likely that at the enzymic level the... 

Payne JF (1977) Mixed function oxidases in marine organisms in relation to petroleum hydrocarbon metabolism and detection. Mar Pollut Bull 8 112-116 Payne JF (1982) Metabolism of complex mixtures of oil spill surfactant compounds by a representative teleost Salmo gairdneri), crustacean Cancer irroratus), and mollusc Chlamys islandicus). Bull Environ Contam Toxicol 28 277-280... 

Payne, J.F. 1977. Mixed function oxidases in marine organisms in relation to petroleum hydrocarbon metabolism and detection. Marine Pollution Bulletin 8 112-116. 

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