Pesticide guideline

As part of the OECD Working Group on Pesticides, guidelines and criteria for industry for the preparation and presentation of complete dossiers and of summary dossiers has been developed. As part of the NAFTA Technical Working Group on Pesticides, the USEPA and PMRA of Health Canada are working together to develop standardized format and content for each industry study report. 

Subdivision O guidelines for residue chemistry data were originally pubHshed by the EPA in 1982. These have been supplemented to improve the rate of acceptance by EPA reviewers of the many reports submitted by registrants in support of tolerances for pesticides in foods. The residue chemistry studies most frequently rejected include metaboHsm in plants, food processing (qv) studies, and studies on storage stabHity of residues in field samples (57). AH tolerances (maximum residue levels) estabHshed under FIFRA are Hsted in 40 CFR under Sections 180 for individual pesticides in/on raw agricultural commodities, 180 for exemptions from tolerances, 185 for processed foods, and 186 for animal feeds. 

Humans and DomesticHnimals. Data from toxicology studies are used to evaluate hazards to humans from the use of pesticides (40 CFR 158.340 and Subdivision F Guidelines). 

Pesticide Assessment Guidelines, Data Requirements Subdivision D, Product Chemistry E, Ha ard Evaluation—Wildlife and Aquatic Organisms F, Ha ard Evaluation—Human and Domestic Animals G, Product Peformance H, Eabeling , Experimental Use Permits J, Ha ard Evaluation—Nontafget Plants K,... 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

International Safety Guidelines for Pesticides Formulation in Developing Countries. Vienna. 

WHO (World Health Organization). 1996. International Programme on Chemical Safety IPCS) The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 1996-1997. Geneva. 

EPA. 1985c. Pesticide chemicals category effluent limitations guidelines, pretreatment standards, and new source performance standards. U.S. Environmental Protection Agency. Federal Register 51 40672-40777. 

Working Group on Pesticides. 1970. Ground disposal of pesticides the problem and criteria for guidelines. Rockville, MD Working Group on Pesticides. WGP-DR-1. 

In 1996, the US Senate and House of Representatives passed the Food Quality Protection Act (FQPA). In order to make their exposure and risk assessments as accurate as possible, the US ERA Office of Pesticide Programs (OPP) has established guidelines to determine a value to assign for NDs. These guidelines can be summarized... 

A method for determining the LOD and LOQ for water samples was proposed by the US EPA. This method has also been discussed by Roy-Keith Smith in his book titled Handbook of Environmental Analysis .The method has also been proposed by the US EPA in their guidelines for Assigning Values to Non-detected/Non-quantitied Pesticide Residues in Human Health Pood Exposure Assessments . ... 

Because of the small number of laboratories involved, validation of UK methods by inter-laboratory study has become impractical in most cases. Even where it is practical, it is usually impossible to validate all pesticide-matrix combinations. Moreover, single-laboratory validation data will have to be generated. Therefore, the CSL guidelines are one of the first that strictly focus on requirements of single-laboratory validation. Some examples of minimum requirements are given in Table 8. Additionally, these guidelines emphasize some other important aspects of validation and contain some new ideas. 

AOAC/FAO/IAEA/IUPAC Expert Consultation, Guidelines for Single Laboratory Validation of Analytical Methods for Trace-level Concentrations of Organic Chemicals, Workshop, 8-11 November 1999, Miskolc, Hungary (1999). Also available on the Word Wide Web http //www.iaea.oi trc/(see pesticides —> method validation). 

---