Peroxisome proliferator-activated receptor atherosclerosis

Fruchart JC, Duriez P, Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 1999 10 245-257. 

Barbier, O., Torra, I. P., Duguay, Y., Blanquart, C., Fruchart, J. C., Glineur, C., and Staels, B. (2002) Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler. Thromb. Vase. Biol. 22, 717-726. 

Li AC, Brown KK, Silvestre MJ, et al. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2000 106(4) 523-531. 

Sueyoshi, S., Yamada, T., Niihasi, M., Kusumi, Y., Oinuma, T., Esumi, M., Tsuru, K., hnai, S., Nemoto, N., Sakura, I., and Mitsumata, M. (2001). Expression of peroxisome proliferator-activated receptor subtypes in human atherosclerosis. Arm. New York Acad. Sci. 947, 429 32. 

Experimental studies indicate that peroxisome proliferator-activated receptors may have a preventive role in the pathogenesis of atherosclerosis by regulating cytokine production, adhesion molecule expression on endothelial cells, fibrinolysis, modulation of monocyte-derived macrophages, and proliferation of vascular smooth muscle cells (Loviscach and Henry 1999, Law et al. 2000). Elangbam et al. (2001) reviewed the current understanding of how peroxisome proliferator-activated receptors are involved in modulating inflammation and atherosclerosis, and their possible therapeutic imphcations. 

Plutzky J. The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis. Am J Cardiol 2003 92 34J-41J. 

Barbier O, Torra IP, Duguay Y, et al. Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler Thromb Vase Biol 2002 22 717-726. 

Li L, Beauchamp MC, RenierG. Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression. Atherosclerosis 2002 165 101-110. 

Neve BP, Fruchart JC, Staels B. Roles of the peroxisome proliferators-activated receptors (PPARs) in atherosclerosis. Biochem Pharmacol 2000 60 1245—1250. 

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