Perfluorooctane sulfonate toxicity

Several studies have suggested that some critical adverse effects like peroxisome proliferation, hepatotoxicity, immunotoxicity, and developmental toxicity may be associated with chemical exposure to PFCs, particularly to PFOS (perfluorooctane sulfonate) and PFOA (perfluorooctanoic acid), two ubiquitous persistent organic pollutants with possible environmental and human health risks. 

This chapter focuses on the 12 most toxic POPs subject to control of the Stockholm Convention. It is recognized that there are other POPs which have been demonstrated to elicit adverse effects of toxicological significance on human health and the environment, for which international agreement has yet to be reached on their inclusion in the Convention list. Indeed, five new POPs candidates (hexabromobiphenyl (6-PBB), pent-abromodiphenyl ether (PBDE), perfluorooctane sulfonate (PFOS), chlordecone and lindane) were proposed and considered at the First Meeting of the POPs Review Committee of the Stockholm Convention in November 2005 (UNEP, 2005). The challenge is for the local scientific... 

Ji K., Kim Y., Oh S., Ahn B., Jo H. Choi K. (2008) Toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid on freshwater macroinvertebrates (Daphnia magna and Moina macro-copa) and fish (Oryzia latipes). Environmental Toxicology and Chemistry 27 2159-2168. 

OSHA PB PBB PBT PEC penta-BDE PFOS PNEC POP PPE PPORD PRODUCE European Agency for Safety and Health at Work Persistent and bioaccumulating Polybromobiphenyl(s) Persistent, bioaccumulative and toxic Predicted environmental concentration Pentabromodiphenyl ether Perfluorooctane sulfonate Predicted no-effect concentration Persistent organic pollutant Personal protective equipment Process/product-oriented research and development Piloting REACH on downstream use communication in Europe... 

Seacat AM, Thomford PJ, Hansen KJ, et al. (2003) Subchronic dietary toxicity of potassium perfluorooctane sulfonate in rats. Toxicology 183 117-131. 

OECD. 2002. Co-operation on Existing Chemicals—Hazard Assessment of Perfluorooctane Sulfonate and its Salts. ENV/JM/RD(2002)17/FINAL. Robust Study Report Reference No. 8 - Early Life-Stage Toxicity Test with the Fathead Minnow Pimephales promelas), pp. 114-117. Available at http / /www.oecd.org/ env/ehs/risk-assessment/2382880.pdf (accessed March 7, 2014). 

Sibley, RK. 2004. Toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid to Chironomus tentans. 23(9) 2116-2123. As cited in ... 

Boudreau, T.M., Sibley, P.K., Mabury, S.A., Muir, D.C.G., and Solomon, K.R. 2003. Laboratory evaluation of the toxicity of perfluorooctane sulfonate (PFOS) on Selenastrum capricornutum, Chlorella vulgaris, Lemna gibba, Daphnia magna and Daphnia pulicaria. Arch. Environ. Contam. Toxicol. 44 307-313. As cited in United Nations Environmental Programme, 2006. Report of the Persistent Organic Pollutants Review Committee on the Work of Its Second Meeting. Addendum Risk profile on perfluorooctane sulfonate. 

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