Perfluorochemical liquid

Weiss DJ, Bonneau L, Allen JM, Miller AD, Halbert CL. Perfluorochemical liquid enhances adeno-associated virus-mediated transgene expression in lungs. Mol Ther2000 2 624-630. 

Lisby DA, Ballard PL, Fox WW, Wolfson MR, Shaffer TH, Gonzales LW. Enhanced distribution of adenovims-mediated gene transfer to lung parenchyma by perfluorochemical liquid. Hum Gene Ther 1997 8 919-928. 

Several techniques have been demonstrated to augment expression following direct airway instillation of vectors, particularly viral vectors. Although the clinical applicability of some of these approaches is unclear, methods utilizing surfactant and the perfluorochemical liquids are based on established clinical use of each of these for treatment of acute lung injury. 

One potential hurdle to gene transfer approaches for pulmonary edema is effective airway delivery of vector to an edematous lung. However, it has recently been demonstrated that administration of adenoviral vector in a 50 50 surfactant saline mixture enhanced gene delivery in a rat model of acute pulmonary edema (70). The use of perfluorochemical liquids during vector administration may also be useful for gene delivery in the setting of pulmonary edema and acute and chronic lung injury (59,151). 

Weiss DJ, Niven RW, Strandjord TP, Liggitt D, Clark JG. Perfluorochemical liquid-enhanced liposomal-mediated gene transfer to lungs of spontaneously breathing rats. Pediatr Pulmonol 1998 17 269. 

Weiss DJ, Baskin GB, Shean MK, Blanchard JL, Kolls JK. Use of perfluorochemical liquid to enhance adenoviral-mediated gene expression in lungs of spontaneously breathing non-human primates feasibility and initial studies. Pediatr Pulmonol 2000 20 (Suppl) 235-236. 

This book presents a unique collection of up-to-date UPLC-MS/MS (ultra performance liquid chromatography-tandem mass spectrometric) methods for the separation and quantitative determination of pesticides, capsaicinoids, heterocyclic amines, aflatoxin, perfluorochemicals, acrylamide, procyanidins and alkaloids, lactose content, phenolic compounds, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. 

Gosetti F, Chiuminatto U, et al. Determination of perfluorochemicals in biological, environmental and food samples by an automated on-line solid phase extraction ultra high performance liquid chromatography tandem mass spectrometry method. Chromatogr A 2010 1217(50) 7864-72. 

BonneauL, Shaffer TH, Lukason M, St. George J, Wollson MR, Weiss DJ. Ingesfion in vivo by alveolar macrophages of perfluorochemical (PFC) liquid correlates with altered pro-inflammatory cytokine release. Am J RespirCrit Care Med 2000 161 A902. 

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