Pentazocine lactate

Tissue damage Severe sclerosis of skin, subcutaneous tissues, and underlying muscle has occurred at injection sites following multiple doses of pentazocine lactate. 

Benzomorphan derivatives pentazocine hydrochloride pentazocine lactate... 

Ultraviolet Spectrophotometry Pentazocine can be determined in pentazocine hydrochloride tablets by a UV spectral method. The sample is extracted with sulfuric acid, basified, extracted with ether and back-extracted into 1 in 70 dilute sulfuric acid. The absorbance of the solution in 0.5 N H2SO1L is determined at 278 nm and compared to that of the standard preparation. A cation exchange column isolation method can be utilized to determine pentazocine in pentazocine lactate injection. Pentazocine is eluted from the column with methanol 6 N HC1 (1 1). Sample absorbance is read at 278 nm and compared to a pentazocine standard at approximately 120-w.g/ mL (3). 

Pentasa mesalazine. pentazocine [ban,inn.jan,usan] (pentazocine hydrochloride [usan] pentazocine lactate [usan] NSC 107430 Fortagesic Fortral Talwin ) is one of the benzomorphan series and is a (mixed partial p and full k) OPIOID RECEPTOR AGONIST with OPIOID ANALGESIC activity. It is used orally or by injection to treat moderate to severe pain, pentazocine hydrochloride pentazocine, pentazocine lactate pentazocine, pentetrazol [ban, inn] (pentylenetetrazole pentamethylenetetrazole) has similar properties to doxapram as a CNS stimulant and respiratory stimulant. It was previously used intramuscularly to treat barbiturate and other CNS depressants in overdose, and orally for bronchial disorders. 

Dosages and routes of administration Pentazocine is used as the hydrochloride or lactate in oral, parenteral and rectal formulations. Doses for the treatment of moderate to severe pain are in the range of 25-100 mg. 

The forms of pentazocine recognized by the U.S.P. include pentazocine base, hydrochloride and lactate salts in the following formulations (1,3,4). 

Pentazocine, USP. Pentazocine. 1.2.3.4.S.6-hcubv-dro-cfs-6,11 -dimethyl-3-(3-mc ihyl-2-butenyl)-2.6-nKili ano3-benzazocin-8-ol. ci.v-2-dimethylallyl-5.9-dimcthyl-l -hydroxy-6,7-benzomorphan (Talwin). iKCurs as a uhic crystallinc powder that is insoluble in water and sparingh". soluble in alcohol. It forms a prly soluble hyclnx lilnidt salt, but is readily soluble as the lactate. 

Pentazocine as the lactate is available in injection form containing the base equivalent of 30 mg/mL. buffered to pH 4 to 5. It should nut be mi.xcd with barbiturate.s. Tablets of 50 mg (as the hydrochloride in combination with naloronc to prevent abuse) are available for oral adminLstration. It is also available in combination with aspirin (Talwin Compound) and with acetaminophen (Talacen). 

---