Penetration drug delivery

While the model helps us understand the chemical structure dependencies of skin permeability, it isn t all that useful for calculating permeability coefficients because of the many iffy assumptions it contains. A different tack has to be taken to gain a sense of the limits, especially the upper limit, of cutaneous drug delivery. There is no lower limit. Even proteins penetrate intact skin to some extent. Some idea of the upper... 

J. Liaw and J. R. Robinson, Ocular penetration en-chancers, in Ocular Drug Delivery Systems (A. K. Mitra, ed.), Marcel Dekker, 1993, pp. 369-381. 

Kompella, U.B. and Lee, V.H.L. 2001. Delivery systems for penetration enhancement of peptide and protein drugs design considerations. Advanced Drug Delivery Reviews 46, 211-245. 

P. Calvo, J. L. Vila-Jato, and M. J. Alonso, Corneal penetration of 14C-indomethacin-loaded nanocapsules, in Methods to Overcome Biological Barriers in Drug Delivery, Kuopio, Finland, 1993, Kuopio University, Department of Pharmaceutical Technology, p. 93. 

Keywords Transdermal drug delivery Skin toxicity Microdialysis In vitro permeation In vitro penetration... 

Nicolazzo JA, Reed BL, Finnin BC (2004b) Modification of buccal drug delivery following pretreatment with skin penetration enhancers. J Pharm Sci 93 ... 

If the medical drug is applied topically to the eye, another important factor for ocular drug delivery and penetration has to be taken in account that is, the precorneal clearance which rapidly reduces the drug amount available for penetration. Thus, it is a major factor to take into consideration while evaluating (transcorneal) absorption. So far, due to experimental limitations, not much thought has been given to precorneal clearance in cell-based in vitro models. 

Temsamani J, Vidal P. The use of cell-penetrating peptides for drug delivery. Drug Discov Today 2004 9 1012. 

By using nanotubes for drug delivery the problem of poor solubility of a considerable number of substances such as many medicines could be overcome. Furthermore, nanotubes can be modified to improve their contact and penetration into target cells. In conclusion, using nanotubes for drug delivery should increase efficiency of the latter and can reduce their side-effects. 

Walters, K.A. (1989). Penetration enhancers and their use in transdermal therapeutic systems. In Transdermal Drug Delivery — Development Issues and Research Initiatives, J. Hadgraft and R.H. Guy, eds. Marcel Dekker, New York, 197-246. 

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