Indomethacin-loaded nanocapsules

P. Calvo, J. L. Vila-Jato, and M. J. Alonso, Corneal penetration of 14C-indomethacin-loaded nanocapsules, in Methods to Overcome Biological Barriers in Drug Delivery, Kuopio, Finland, 1993, Kuopio University, Department of Pharmaceutical Technology, p. 93. 

Finally, Skiba et al. report the in vivo application of indomethacin-loaded nanocapsules, prepared from amphiphilic jS-CyD substituted on the secondary face by Ce chains, jS-CyDCe, in a rat model [48]. They compared the rat gastric ulcerative effect of encapsulated indomethacin with that of the indomethacin solution (Indoc-id ). Independently of the administered dose, the ulcerative effect was significantly decreased while the bioavailability of indomethacin was maintained. Gastrointestinal ulcer protection by encapsulation of indomethacin in jS-CyDC nanocapsules was 82% for 5 mg kg and 53% for 10 mg kg administered dose. 

N Ammoury, H Fessi, JP Devissaguet, M Allix, M Plotkine, RG Boulu. Effect on cerebral blood flow of orally administered indomethacin-loaded poly (isobutylcyanoacrylate) and poly(d,l-lactide) nanocapsules. J Pharm Pharmacol 42 558-561, 1990. 

N Ammoury, H Fessi, JP Devissaguet, M Du-brasquet, S Benita. Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(-isobutyl-cyanoacrylate) nanocapsules in rats. Pharm Res 8 101-105, 1991. 

Oral Delivery Amphiphilic P-CD nanocapsules loaded with indomethacin have been evaluated in vivo. The nanocapsules have been applied to the rat model. It was reported that the gastrointestinal mucosa of the rat was significantly protected from the ulcerogenic effects of the active ingredient indomethacin in free form. Drug encapsulation yield in the nanocapsules were >98% and the drug content per CD unit was 7.5% w/w [89],... 

Skiba, M., Morvan, C., Duchene, D., and Puisieux, F., (1995), Evaluation of the gastrointestinal behaviour in the rat of amphiphilic P-cyclodextrin nanocapsules loaded with indomethacin, Int. J. Pharm., 126,275-279. 

---