Pencycuron

Cyclopentanone 1 carboxylic acid lenacil Cyclopentylamine pencycuron... 

Phenyl isocyanate carbetamide, desmedipham, fenuron, forchlorfenuron, metobromuron, pencycuron, propham, siduron, thidiazuron Toluyl sulfonyl methyl fludioxonil m.Tolyl phenmedipham... 

To increase the marketability of Collego, its compatibility with chemical pesticides has been investigated. Mixtures of CGA with propanil [N-(3,4-dichlorophenyl)propanamide], molinate [S-ethyl hexahydro-lH-azepine-l-carbothioate], 2,4,5-T, and benomyl [methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate] were detrimental to CGA s efficacy (31). If, however, propanil, 2,4,5-T, fentin hydroxide (triphenyltin hydroxide), pencycuron N-[(4-chlorophenyl)methyl]-N-cyclopentyl-N -phenylurea), each at 0.56 kg ai/ha, and SN-84364 [3 -isopropoxy-2-(trifluoromethyl) benzanilide] (at 0.40 kg ai/ha) were applied after CGA treatment, disease and development were not inhibited (32). The herbicides, acifluorfen 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid) (0.56 kg ai/ha) and bentazon [3-(1-methylethyl)-(IH)-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide] (0.56 to 1.1 kg ai/ha), or the insecticides, malathion [diethyl(dimethoxyphosphinothioylthio)succinate] (0.56 kg ai/ha) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate), (0.56 kg ai/ha) could be applied with CGA from a single tank mixture (33-34). ... 

Chlorophenyl)melhyl)-N-cyclopentyl-N -phenylurea EINECS 266-096-3 EPA Pesticide Chemical Code 128823 Monceren NTN 19701 Pencycuron, Urea, N-((4-chlorophenyl)methyl)-N-cyclopentyl-N -phenyl-. Non-systemic fungicide used fro control of Rhizoctonia and Pellicularia spp. in potatoes, rice, cotton and vegetables. In... 

Although the use of deuterium in drug metabolism involving the isotope cluster technique may be complicated by isotope effects, both cost and convenience have led most workers to rely on this isotope. Recent examples include reports on aminopyrine,pencycuron, phencyclidine, fentanyl, and diethylstilbestrol. In the case of steroids and their derivatives, ion cluster studies have been performed exclusively with deuterium-labeled substrates. Examples include investigations with [ HsJethynylestradiol,[ H2]4-hydroxyandrost-4-ene-3,17-dione, ]-ursodeoxycholic acid, " and [ Jbudesonide. ... 

B4 20 CeU division (prop) Phenylnreas Pencycuron Specific for Rhizoctonia sotani... 

Pencycuron induces abnormal branching of the hyphae of the sensitive strains of R. solani and its activity is fungistatic [2]. This morphological change implied that the mode of action of pencycuron would be antimicrotubular, like carbenda-zime, and thus it is classified as B4 Cell Division in the FRAC code list. However, while carbendazime inhibits yS-tubuline assembly in mitosis of R. solani, pencycuron does not act there but acts to destroy the cytoskeleton of microtubules. A clear-cut explanation of the mode of action of pencycuron is not yet available. Especially, the mechanistic elucidation as to why pencycuron acts only on quite limited strains of Anastomosis Groups of R. solani remains as an interesting theme. 

Figure 16.2.2 summarizes the perceived primary activity and each milestone compound on the way to reaching pencycuron. The compound was found in an indication shift Normally chemists synthesize new compounds intended for a particular activity. With pesticides inquiry, however, a new finding was often seen in a different area from the anticipated one. For instance, the development of pencycuron originated from what was primarily a herbicide project. 

Fig. 16.2.2. Milestone compounds leading to pencycuron in chemical modification.

Pencycuron, a Phenylurea Fungicide for Rhizoctonia solani S95 Table 16.2.1 Pot test results of the derivatives modified from urea herbicides. 

Phenylisocyanate (IV) was then added to a solution of (III) in toluene, furnishing N-4-chlorobenzyl-N-cyclopentyl-N -phenylurea (pencycuron) as a white solid (mp 129-134 °C). 

C-Labeled pencycuron was applied to four strains of R. solani that differed in sensitivity to this fungicide [3]. Since there no metabolites existed in the medium and mycelia tested, which showed stronger fungicidal activity than the parent compound, it was suggested that pencycuron itself is ultimately the active substance, and metabolic activation or detoxification is less important in explaining the differences among the strains in sensitivity to pencycuron. 

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