Pencycuron metabolism

Although the use of deuterium in drug metabolism involving the isotope cluster technique may be complicated by isotope effects, both cost and convenience have led most workers to rely on this isotope. Recent examples include reports on aminopyrine,pencycuron, phencyclidine, fentanyl, and diethylstilbestrol. In the case of steroids and their derivatives, ion cluster studies have been performed exclusively with deuterium-labeled substrates. Examples include investigations with [ HsJethynylestradiol,[ H2]4-hydroxyandrost-4-ene-3,17-dione, ]-ursodeoxycholic acid, " and [ Jbudesonide. ... 

C-Labeled pencycuron was applied to four strains of R. solani that differed in sensitivity to this fungicide [3]. Since there no metabolites existed in the medium and mycelia tested, which showed stronger fungicidal activity than the parent compound, it was suggested that pencycuron itself is ultimately the active substance, and metabolic activation or detoxification is less important in explaining the differences among the strains in sensitivity to pencycuron. 

Toxicology, Eco-toxicology and Metabolism 16.2.5.1 Toxicology and Eco-toxicology of Pencycuron... 

The metabolic fate of pencycuron in rice plants has been investigated with [phenyl-U- C]pencycuron [11]. When leaves were treated with [ C]pencycuron the radiocarbon gradually penetrated into the leave tissues and part of them showed an acropetal movement. Most radiocarbon was, however, retained on the leave s surface. Pencycuron remained as a major component (52% of the applied... 

Scheme 16.2.2. Metabolic pathways of [ C]pencycuron in rice plants.

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