Pathogenic proteins

Knowledge of (he tjmfrriifnHuinnal imiehtAB nf pathogenic proteins (e.g., viruses) is important in the design of peptide vaccines. Rather than trying all possible peptides, one only needs to try those peptides that are predominantly... 

A multitude of bacterial pathogen proteins have been characterized and crystallized recently. Amongst them, cofactors of human serine proteinases or their zymogens... 

New Jersey Commission on Science and technology, and Rutgers University (Pis-cataway, NJ) Metazoan organisms, human pathogen proteins http //www-nmr.cabm. Rutgers.edu/... 

Pathogen Protein Species Binding Properties and Mechanism of Action Reference... 

Therefore, the altered protein possesses the essential properties of a disease-causing agent it has a damaging effect and is able to propagate itself. The unique feature of this pathogenic protein is that in contrast to all previously known infectious agents it is apparently able to propagate itself without the help of nucleic acids. Prusiner named his discovery prion... 

Direct injection of DNA could also be used to vaccinate patients against pathogens as evidenced by the effects of direct injection of plasmid DNA encoding pathogen proteins or immunomodulatory cytokines [133,134], Direct injection may also be an effective way to systemicaUy dehver therapeutic proteins [135], For example, the incidence of autoimmune diabetes in a mouse model of the disease was significantly reduced in mice that were injected intramuscularly with DNA encoding IL-10, an immunosuppressive cytokine [136],... 

Very intriguing is the multi-faceted musde degeneration in s-IBM and its many similarities to the complex neuronal degenerations occurring both in Alzheimer and Parkinson disease brains. The similarities include (a) abnormal accumulations of many of the same putatively pathogenic proteins, (b) their similar posttranslational modifications, and (c) similar defective mechanisms of protein disposal those contribute to the observed abnormal protein aggregations, P-pleated sheet amyloid accumulation, and cytoplasmic vacuolization. 

Dyer, M. D., T. M. Murali, and B. W. Sobral. (2007). Computational prediction of host-pathogen protein-protein interactions. Bioinformatics 23 il59-166 Jul 1. 

We will first treat the adhesion of a pathogenic protein via the long route crossing both glycosphingolipids and cholesterol. In the beginning, the protein "sees" only the glycone part of the glycolipid, which extrudes from the membrane (Fig. 13.2). 

At this stage, the pathogenic protein is attached to the glycolipid but does not "know" yet that cholesterol is just below (Fig. 13.2). The interaction of the protein with cholesterol is a two-time process. The first step is the recognition of the OH group of cholesterol by the protein. It requires that this OH group is not already engaged in an interaction with vicinal... 

FIGURE 13.6 Dual use of glycosphingolipids and cholesterol by pathogenic proteins. (A) In this model, a... 

How to Prevent the Interaction of Pathogenic Proteins with Brain Membranes... 

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