Transdermal patches matrix-controlled

The transdermal dmg formulations could be in the form of a suspension, solution, gel, ointment, or multilayer transdermal patch. A controlled dmg release from the patch is usually achieved by changing the properties of either the rate-controlling membrane or the dmg matrix. 

Transdermal Drug Administration Controlled with Matrix Diffusion Drug administration through the skin was first achieved with hydrogel-type patches, that are polymer matrixes [4,22,61,75]. Matrix diffusion is characteristic... 

Rovati LC, Setnikar I, Genazzani AR. Dose-response efficacy of a new estradiol transdermal matrix patch for 7-day application a randomized, double-blind, placebo-controlled study. Italian Menopause Research Group. Gynecol Endocrinol 2000 14(4) 282-91. 

De Aloysio D, Rovati LC, Giacovelli G, Setnikar I, Bottiglioni F. Efficacy on climacteric symptoms and safety of low dose estradiol transdermal matrix patches. A randomized, double-blind placebo-controlled study. Arzneimittelforschung 2000 50(3) 293-300. 

Arrenbrecht S, Boermans AJ. Effects of transdermal estradiol delivered by a matrix patch on bone density in hysterectomized, postmenopausal women a 2-year placebo-controlled trial. Osteoporos Int 2002 13(2) 176-83. 

There is a wide variety of transdermal systems on the market at present. These patches are diversely referred to as reservoir , monolithic , membrane-controlled , adhesive , matrix , and so on. Unfortunately, these terms are not always used consistently and, worse, they are sometimes used inaccurately. In all cases, however, the idea is that the system offers a means to hold a payload of the drag and a configuration (or platform ) to ensure presentation of the active agent to the skin surface at a rate sufficient to ensure a systemic pharmacological effect after the drag has crossed the skin s barrier. Most simplistically, one can divide the transdermal formulations presently available into three categories (Figure 8.3) ... 

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