Partition coefficients determination

Slater, B., McCormack, A., Avdeef A., Comer, J. E. pH-metric logP. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values. J. Pharm. 

Leahy, D. E. Taylor, P. J. Wait, A. R., Model solvent systems for QSAR. 1. Propylene glycol dipelargonate (PGDP). A new standard for use in partition coefficient determination, Quant. Struct. Act. Relat. 8, 17-31 (1989). 

Pearlman, R. S. (1986) Molecular surface area and volume Their calculation and use in predicting solubilities and free energies of desolvation. In Partition coefficient, Determination and Estimation. Dunn, III, W. J., Block, J. H., Pearlman R. S., Eds., pp. 3-20, Pergamon Press, New York. 

Berthod, A., Menges, R.A., Armstrong, D.W. (1992) Direct octanol-water partition coefficient determination using co-current... 

Gluck, S.J., Martin, E.J. (1990) Extended octanol-water partition coefficient determination by dual-mode centrifugal partition chromatography. J. Liq. Chromatogr. 13, 3559-3570. 

Tomlinson E, Hafkenscheid TL (1986) In Dunn WJ III, Block JH, Pearlman RS (eds) Partition coefficient, determination and estimation. Pergamon Press, New York, p 101... 

Ottaviani, G., Martel, S., Escalara, C., Nicolle, E. and Carrupt, P.A. (2008) The PAMPA technique as a HTS tool for partition coefficients determination in different solvent/water systems. European Journal of Pharmaceutical Sciences,... 

Chondrite-normalized abundances of siderophile elements in the Earth s mantle. The measured concentrations do not match those expected from low-pressure metal-silicate partition coefficients determined by experiments. Modified from Tolstikhin and Kramers (2008). 

Kchiorofoim is the partition coefficient determined between chloroform and an aqueous phase, the pH of which was such that the drug was largely in the nonionized form. 

Filser, 1993 Kohn Melnick, 1993 Bond et al., 1994 Medinsky et al., 1994 Csanady et al., 1996 Sweeney et al., 1997) predicted, species specifically, similar toxicokinetic behaviour of butadiene. The only exception was the first model of Kohn and Melnick (1993), which contained much higher theoretically derived partition coefficients than the experimentally determined ones, leading to prediction of butadiene storage in fat tissue. In a second, extended version, the authors used average values of the partition coefficients determined experimentally by Johanson and Filser (1993) and Medinsky etal. (1994). 

Tomlinson, E., and T. Hafkensheid. 1986. The Filter Probe Extractor A Versatile Tool for the Rapid Determination of Solute Oil/Water Distribution Behavior. In Partition Coefficient Determination and Estimation, W.J. Dunn III, J.H. Block, and R.S. Pearlman, Eds., 83-99, Pergamon Press, N.Y. 

A particularly large dataset has come from the study of cuticle-water partition coefficients determined using batch experiments with isolated cuticles (Kerler and Schonherr, 1988). The cuticle, a lipophilic membrane covering all leaves, is an important storage compartment for lipophilic organic compounds in vegetation. 

Maitani, Y., A. Coutel-Egros, Y. Obata, and T. Nagai. 1993. Prediction of skin permeabilities of diclofenac and propranolol from theoretical partition coefficients determined from cohesion parameters. ]. Pharm. Sci. 82(4) 416-420. 

Tomlinson, E., Hafkenscheid, T.L. (1986) Aqueous solubility and partition coefficient estimation from HPLC data. In Partition Coefficient, Determination and Estimation. Dunn, HI, W.J., Block, J.H., Pearlman, R.S., Editors, pp.101-141. Peigamon Press, New York. 

V. Lee, "Synthesis of (14C)Methylsi anes and Their Octanol-Water Partition Coefficient Determinations," M.S. thesis, San Jose State College, San Jose, Cal., 1967. 

Polyaromatic hydrocarbons Dimethyl sulphoxide - - Partition coefficients determined - [211]... 

El Tayar et al., using micelle-water (mw) partition coefficients determined on a polyoxyethylene(23)-lauryl ether column [31], found a significant correlation between log Pmw and the activity of a series of antiplatelet agents, but no correlation when using log Poet. or calculated [10] log P-values (CLOGP) parameters. 

Similarly, another study on NSAIDs came to the conclusion that the partition coefficients determined on immobilized artificial membranes are more suitable for... 

W. J. Dunn, J. H. Block, and R. S. Pearlman, Partition Coefficient Determination and Estimation, Pergamon, New York, 1986. 

Mirrlees MS, Moulton SJ, Murphy CT et al. (1976) Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography. J Med Chem 19 615-619 Pagliara A, Khamis E, Thrinh A et al. (1995) Structural properties governing retention mechanisms on RP-HPLC stationary phases used for lipophilicity measurements. J Liquid Chromatography 18 1721-1745 Slater B, McCormack A, Avdeef A et al. (1994) pH-Metric log P. 4. Comparison of Partition Coefficients Determined by Shake-Flask, HPLC and Potentiometric Methods. J Phar-maceut Sci 83 1280-1283... 

Another important factor is the influence of drug ionization on the partition coefficient and this is particularly important when a buffer is used instead of water. The partition coefficient determined from Equation (14) is an apparent value rather than a true partition coefficient for ionic drugs. However, the true partition coefficient can be calculated from the apparent partition coefficient if the drug s pA a and the pH of the drug solution are known [39], as shown in the equations... 

Jepson, G.W., Hoover, D.K., Black, R.K. (1994). A partition coefficient determination method for nonvolatile chemicals in biological tissues. Fundam. Appl. Toxicol. 22 519-24. 

In the early stage of preformulation, characterization of the drug molecule involves ionization constants and partition coefficient determinations, aqueous and nonaqueous kinetic and equilibrium solubility determination, pH solubility profile, chemical stability assessment, and salt and polymorph screening. Assessment of biopharmaceutics and toxicological screening are also essential... 

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