Particulate contamination glass

Once the solution has been filtered to remove gross particulate contamination—glass wool in a Pasteur pipet is convenient for small volumes—proceed to the supersaturation stage. The most common methods of supersaturating a solution (i.e., raising the concentration of a dissolved compound above its saturation solubility) are evaporation and cooling. 

Use latex gloves, impervious laboratory apron or clothing, and full-face shields when handling these compounds. In the event of a spill, wipe up with absorbent paper and then clean with methylene chloride, methanol, and a detergent. The contaminated papers, clothing, and so on, should be placed into a hazardous waste drum. Contaminated glasses should be compacted in a hazardous waste trash compactor and placed in a waste disposal drum. Effluents from hoods, GC/MS, and vacuum pumps should be passed through HEPA particulate Alters and charcoal. 

Scattering caused by defects in the glass such as particulate contamination and bubbles... 

As with all pharmaceutical preparations, radiopharmaceuticals should undergo a visual examination. The examination should take into account radiation protection issues for the operator and be conducted as quickly as possible with the preparation behind suitable shielding. Vials should be examined for insecure closures, cracks, glass particles in the liquid, and particulate contamination. Syringes should also be examined for particulate contamination. 

Tensmeyer et al. (1981) developed a sterihzation method for empty glass containers, using a laser and a microwave oven. Sterihzation procedures were evaluated at power levels upto 2000 Watts. It was observed that spore destruction was logarithmically related to the exposure time. B. subtilis spores were used to check the efficiency. All the spores got destroyed with no particulate contamination being introduced into the glass containers. 

This test is to assess the efficacy of the vial/ampoule washer in reducing the particulate level in contaminated vials. Particulate matter to be determined in eight vials/ampoules, each spiked with approximately 500 particles of 40- im glass beads. A sample is to be taken from each individual needle at the end of vial/ampoule washing at set operational parameter of vial/ampoule washer and analyzed to determine the reduction in particulate level. The X ml vials/ampoules are to be washed according to the operational parameters described for each vial/ampoule size. The results are to be compared with negative and positive controls. The test results for each size of vial/ampoule are to be entered in Table 2. 

In some designs, a glass fiber filter is supported above the extraction disc to prefilter samples containing particulates without clogging the extraction disc. Because of the rigid disc design, frits to support the extraction disc are not necessary. The polyethylene frits used in conventional SPEi columns may be a source of contamination (90) and have a large surface area and void volume. 

The first deployment of CBPC for stabilization of Hg using Ceramicrete was reported by Singh et al. [58]. These authors used the CBPC process to stabilize crushed Hg light bulbs that were radioactively contaminated. Visual inspection of the waste revealed that 90 vol% of the waste was <60 mm in size. Typical size of the crushed glass ranged from 2 to 3 cm long by 1-2 cm wide down to fine particulates. Chemical analysis indicated... 

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