Partial model building

The distribution of a compound in the human body can also be partially related to the absorption properties. There are specific transport systems that are expressed in certain tissues that can influence the distribution of the compound. For example, rosuvastatin, a new member of the statin family is transported by the OATP-C carrier system, which is selectively expressed in the liver, making this compound selectively distributed into this organ [27]. In general it is not possible to derive computational models for these selective transport systems since there is not yet enough experimental information and data to support the model building and validation. Nevertheless, there are three properties that are commonly used to describe the distribution of a compound in the human body the solubility, the unspecific binding of the compound to plasma proteins and the volume of distribution. 

Vertically, VeDa is partitioned into five partial models, representing thematically distinct areas. The partial models Structural Modeling Objects and Behavioral Modeling Objects describe mathematical models from a structural and behavioral viewpoint, respectively. The description of mathematical models is complemented by the remaining partial models, which represent geometrical concepts, materials, and the process of model building. 

On the Conceptual Layer, the CAPE domain is represented by four major partial models The central chemicaLprocesssystem represents all those concepts that are directly related to materials processing and plant operating - just like the identically named partial model in CLiP. The partial model material provides an abstract description of materials involved in a chemical process, whereas model defines notions required for a description of models and model building. Finally, the partial model supporting-concepts supplies... 

For each activity, there is information about the subject matter to be processed, a necessary work tool, a skill profile of possible persons to execute the activity, input and output information of the activity, and a duration distribution. The distribution of the duration includes an expected value and a variance value. The distribution of the time consumption (e.g., Gaussian, right- or left-skewed /3-distribution) may also be used for the calculation of possible buffer times. For the execution of an activity, a qualified person and, if necessary, adequate tools are selected to achieve the goal of the activity. As a result, the net for the representation of the execution of a single activity builds the link between the partial models of the work tool and the employee (Person Net and Tool Net, see below). 

First, document contents models for any of the documents to be integrated have to be refined and formalized, providing enough details for the tool building process (see a) of Fig. 6.5). A basis for that are the application document contents models (see upper part of Fig. 6.5) that specify which entities of partial models are relevant for which document. The definition of the corresponding entities and some of their relationships can be extracted from the ontologies. 

Generic building blocks or basic constructs are modeling elements with which the requirements and solutions for a particular enterprise can be described. Partitil models, which are partially instantiated CIMOSA solutions applicable to one or more industrieil sectors, are tilso provided in the reference architecture. The user can customize partial models to a part of the model of his or her particular enterprise. The CIMOSA modeling framework ensures that partied models from different sources can be used to build a model of one particular enterprise. 

The fourth summation corresponds to an energy function for all atoms j not directly bonded to atom /, and represented by a van der Waals attractive and repulsive energy term. This term is essential for nucleic acid model building in order to maintain a reasonable base stacking such that the stacked base planes are approximately parallel and separated by about 3.4 A. In addition to this, the fourth summation is used to constrain certain specified pairs of atoms at hydrogen bond distances. Thus, we initially specified in the refinement the base-paired secondary structure as well as the tertiary structure hydrogen bonds which could be seen in the MIR and partial group structure Fourier maps. 

Principal Component Regression (PCR) and Partial Least Squares (PLS) ForPCRandPLS calibration model building, it is assumed that spectral data can be... 

Post-Earthquake Diagnosis of Partially Instrumented Building Structures Seismic Analysis of Masonry Buildings Numerical Modeling... 

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