Paregoric

In 58 percent of cases, symptomatic treatment with Valium, pheno-barbital, or paregoric, for a period ranging from 2 to 14 days, was required to control drug effects. However, in 42 percent of the cases, symptoms were successfully managed with more conserva-... 

How many milliliters of paregoric and how many grams of pectin are present in each 15-mL dose ... 

Opioids. Activation of opioid receptors in the enteric nerve plexus results in inhibition of propulsive motor activity and enhancement of segmentation activity. This antidiarrheal effect was formerly induced by application of opium tincture (paregoric) containing morphine. Because of the CNS effects (sedation, respiratory depression, physical dependence), derivatives with peripheral actions have been developed. Whereas diphenoxylate can still produce clear CNS effects, loperamide does not Lullmann, Color Atlas of Pharmacology... 

Paregoric Opium Tincture (lauda- Pitocin Oxytocin... 

Caution - Opium tincture contains 25 times more morphine than paregoric. Do not confuse opium tincture with paregoric this may lead to an overdose of morphine. 

Opium Diarrhea caused by poisoning until the toxic material is eliminated from the Gl tract use in children (opium tincture only) convulsive states such as those occurring in status epilepticus, tetanus, and strychnine poisoning (Paregor/c only). Oxycodone ... 

Octreotide (Sandostatin, Sandostatin LAR) Paregoric [Camphorated Tincture of Opium]... 

Paregoric [Camphorated Tincture of Opium] [C lll] [Narcotic Antidiarrheal] Uses D, Pain neonatal opiate withdrawal synd Action Narcotic Dose Adults. 5—10 mL PO daUy-qid PRN Peds. 0.25-0.5 mL/kg daily-qid Neonatal withdrawal 3-6 gtt PO q3-6 h PRN to relieve Sxs x 3-5 d, then taper ovo 2-4 wk Caution [B (D w/ prolonged use/high dose near term, +]... 

Opium Street Names Auntie Emma, big O. black stuff, block, gum, hop, ope, tar (brand generic called tincture of opium, laudanum, paregoric (CIII), B O suppositories [CIII]) Use Some medical uses (antidiarrheal, antitussive, antispas-modic) illegally used to produce morphine and h oin can be swallowed or smoked Actions Narcotic contains morphine Effects Pain relief, euphoria, drowsiness/N, constipation, confusion, sedation, resp dqjression and arrest, tol -ance, addiction, unconsciousness, coma, death... 

Babies bom to opioid-addicted women also exhibit withdrawal signs, but because of the slower metabolism of opioids in the newborn, the withdrawal signs are more protracted. The babies are often treated with the opium preparation paregoric to reduce withdrawal signs. 

The use of opium dates to 4,000 b.c. At that time it was used for medicinal and recreational purposes mainly via inhalation. Today few opium-containing preparations are used, since the activity of opium is largely attributed to its morphine content. The preparations in use today are those that have constipative effects useful for the treatment of diarrhea. Preparations include pantopon, an injectable hydrochloride of opium alkaloids, and paregoric, a camphorated tincture of opium. Paregoric can be used to treat infants with opioid withdrawal signs following in utero exposure to opioids. 

The more widely used paregoric (camphorated opium tincture) is equally effective and is frequently used in combination with other antidiarrheal agents. Codeine also has been used for short-term symptomatic treatment. 

Opium Laudanum, paregoric Big 0, black stuff, black gum, hop II, III, V Swallowed, Smoked ... 

Diarrhea from almost any cause can be controlled with the opioid analgesics, but if diarrhea is associated with infection such use must not substitute for appropriate chemotherapy. Crude opium preparations (eg, paregoric) were used in the past to control diarrhea, but now synthetic surrogates with more selective gastrointestinal effects and few or no CNS effects, eg, diphenoxylate or loperamide, are used. Several preparations are available specifically for this purpose (see Chapter 62). 

Opioid derivatives used to treat diarrhea are listed in Table 27-3. Opium tincture (laudanum) and camphorated opium tincture (paregoric) are naturally occurring opiates that are very potent inhibitors of peristalsis. These natural agents are still available for treating diarrhea, but they have essentially been replaced by newer opioids such as diphenoxylate and loperamide. These newer opioids are somewhat less potent but may produce fewer side effects. 

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