Camphorated tincture of opium

Treatment of severe diarrhea and intestinal cramping (camphorated tincture of opium)... 

Octreotide (Sandostatin, Sandostatin LAR) Paregoric [Camphorated Tincture of Opium]... 

Paregoric [Camphorated Tincture of Opium] [C lll] [Narcotic Antidiarrheal] Uses D, Pain neonatal opiate withdrawal synd Action Narcotic Dose Adults. 5—10 mL PO daUy-qid PRN Peds. 0.25-0.5 mL/kg daily-qid Neonatal withdrawal 3-6 gtt PO q3-6 h PRN to relieve Sxs x 3-5 d, then taper ovo 2-4 wk Caution [B (D w/ prolonged use/high dose near term, +]... 

The use of opium dates to 4,000 b.c. At that time it was used for medicinal and recreational purposes mainly via inhalation. Today few opium-containing preparations are used, since the activity of opium is largely attributed to its morphine content. The preparations in use today are those that have constipative effects useful for the treatment of diarrhea. Preparations include pantopon, an injectable hydrochloride of opium alkaloids, and paregoric, a camphorated tincture of opium. Paregoric can be used to treat infants with opioid withdrawal signs following in utero exposure to opioids. 

Papaver somniferum (opium poppy) contains a variety of opioid and related alkaloids, including codeine, morphine, noscapine, papaverine, and thebaine. Crude opium is the air-dried latex obtained by incising the unripe capsules of P. somniferum. Paregoric is ammoniated tincture of opium (Scotch paregoric) or camphorated tincture of opium (English paregoric). The use of these formulations has largely been replaced by use of the purified compounds. 

The constipating effect of orally administered opiates can be used for the treatment of diarrhea, as with camphorated tincture of opium (Paregoric or Parepectolin, which is a paragoric plus kaolin as an adsorbent and pec-... 

Caz horated Tincture of Opium. (Paregoric Elixir). This is a camphorated tincture of opium. Macerate X drachm each powdered opium and benzoic acid, 1 fluid drachm oil of anise, 2 ounces clarified honey, and 2 scruples camphor, in 2 pints dilut alcohol for 7 days, and filter through paper. (27. S. Ph.)... 

Mix together 1 ouuco essence of Jamaica ginger 2 ounces ca[Pg.326]

Camphorated Tincture of Opium, B.P, (Paregoric). A compound tincture composed of benzoic acid, camphor, anise oil and tincture of opium, in alcohol. It contains 0 05 per cent w/v of anhydrous morphine. 

Concentrated Camphorated Tincture of Opium, B.P.C, Eight times the strength of the camphorated tincture. For assay it is diluted eight times with 60 per cent ethanol and one of the above methods employed. 

Mix intimately 1 g of sample with 0 25 g of slaked lime in a glass mortar. Add water gradually and transfer quantitatively to a 100-ml graduated flask. Shake the mixture (approximately 90 ml) frequently during thirty minutes, make up to 100 ml, shake and filter. To 10 ml of filtrate add 015 g of ammonium sulphate and continue the nitroso-morphine colorimetric assay as given under Camphorated Tincture of Opium except that the residue is dissolved in 5 ml of N hydrochloric acid and diluted to 50 ml. 20 ml of this solution is used for the colorimetric assay. 

Weigh 4 g into a small dish and evaporate the volatile solvents on a water-bath. Triturate the residue with 1 ml of dilute ammonia solution until a smooth cream is obtained and continue as described above for Camphorated Tincture of Opium beginning with the words add chromatographic aluminium oxide. . . and ending with the words. to about 1-5 ml per minute by means of gentle suction. Extract the morphine from the eluate with 10, 10 and 5 ml of 2 per cent w/v sulphuric acid solution, combine the extracts in another separator and make alkaline to litmus paper with dilute ammonia solution. Complete by the method for Mixture of Ammonium Chloride and Morphine from the words shake vigorously for two to three minutes. . . , but dissolve the residue in exactly 5 ml of 0-5N hydrochloric acid and dilute with water to 50 ml. Use 10 ml of this solution for application of the iodic acid-nickel chloride reaction described above. 

---