Parasite drag

The Wrights were veiy conscious of the importance of parasite drag, which in their day was called head resistance. They used empirical formulas obtained from Octave Chanute to esti-... 

It is the author s belief that systems utilizing low volumetric flow rates with minimized parasite drag, such as hollow fibers, will find Increased use in the future. 

Conceptually, hollow fibers are the ideal membrane configuration. There is no "parasite drag" and no expensive porous support tube. The fibers may be pressurized on the inside (up to 30 psig) permitting "thin-channel" fluid management of the feed stream (refer to Figure 3.13). 

Equation (6.31) gives some indication of how to amplify the yield stress, i. e. by fixing the value of l/h in the valve. For example, if Z = 100 mm and h = 0.5 mm, then APg = 400Tg. This type of manipulation is, of course, familiar to a hydraulics engineer, who often uses a small shear stress to effect a high pressure drop to drive a piston. It is, after all, why shock absorbers and actuators are usually of the piston type rather than of the shear plate variety, and why fluid-based damper devices are preferred to purely electrical types. However the choice of shear plates can significantly reduce shear rate and hence parasitic drag. 

In leishmaniasis, macrophages are infested by the parasite. A hypothetical anti-leishmanial drag is strongly hydrophilic and positively charged at physiological pH. What targeting system would you recommend to develop if a fast market introduction is desirable ... 

Disease control is hampered by the occurrence and increase of multi-drag-resistant strains of the malaria parasite Plasmodium sp. Many species affect humans though p. falciparum, is responsible for the most severe illnesses and deaths attributable to malaria in sub-Sahara Africa and in certain areas of South-East Asia and the Western Pacific (7). 

The use of chemicals to try and eradicate parasites, bacteria, viruses or cancer cells in the body is culled chemotherapy. It depends on the drufs being selectively toxic, i.e. toxic to the cells of the ptira-site. but not (too) toxic to the human host. Bacteria have many biochemical differences from human cells, and some amibaierial drags are strikingly non-ioxic to human.s. On the other hand, because cancer cells arc so simitar to normal cells, roost aniicancer drags show little. selective toxicity and therefore produce serious adverse effects (Chapter 43). 

The binding of 8-amlnoquinollne antlmalarials to DNA conqparable to that with chloroquine has been reported.7° effect on DNA fxmction may be involved with antimalarlal activity. Co-en nne Q which is associated with the mitochondrial oxidation of DPNH and succinate and is present in the metabolism of the parasite has been shown to be inhibited by chloroquine, primaquine, quinacrine and menoctone (IV), thus suggesting diversity of action for antimalarial drags.77... 

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