Papillary serous carcinoma

Goldstein NS, Uzieblo A. WTl immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas. Am J Clin Pathol. 2002 117 541-545. 

Tong GX, Chiriboga L, Hamele-Bena D, Borczuk AC. Expression of PAX2 in papillary serous carcinoma of the ovary immunohistochemical evidence of fallopian tube or secondary Mullerian system origin Mod Pathol. 2007 20 856-863. 

Zhou J, Iwasa Y, Konishi I, et al. Papillary serous carcinoma of the peritoneum in women A clinicopathologic and immunohistochemical study. Cancer. 1995 76 429-436. 

Zheng WX, Khurana R, Farahmand S, et al. p53 immunostain-ing as a significant adjunct diagnostic method for uterine surface carcinoma—Precursor of uterine papillary serous carcinoma. Am J Surg Pathol. 1998 22 1463-1473. 

Liang SX, Chambers SK, Cheng L, et al. Endometrial glandular dysplasia A putative precursor lesion of uterine papillary serous carcinoma. Part II molecular features. Int J Surg Pathol. 2004 12 319-331. 

Slomovitz BM, Broaddus RR, Burke TW, et al. Het-2/neu ovetexptession and amplification in uterine papillary serous carcinoma. J Clin Oncol. 2004 22 3126-3132. 

Rose PG, Nelson BE, Reale FR (1992) False-positive elevation of CA-125 in papillary serous carcinoma of the endometrium treated with postoperative whole abdominal radiation. Gynecol Oncol 47 127-129... 

Mills SE, Andersen WA, Fechner RE, et al. Serous surface papillary carcinomas A clinicopathologic study of 10 cases and comparison with stage III-IV ovarian serous carcinoma. Am J Surg Pathol. 1988 12 827-834. 

It is easy to recognize endometrial serous carcinoma when it is tumor forming and present in its characteristic papillary form with bizarre tumor cell nuclei. However, endometrial serous carcinoma can be difficult to diagnose... 

Lymph node dissection is also recommended in histological subtypes associated with a higher risk of lymph node metastasis (e.g., clear cell, serous papillary endometrial carcinoma). Pelvic lymph node dissection should be performed in combination with para-aortic lymph node dissection because of the high risk of metastasis at both sites [24]. Whether lymphadenectomy is curative in endometrial cancer remains controversial [38]. 

Primary malignant neoplasms of the fallopian tube are extremely rare and account for only 0.3%-l.l% of all gynecologic cancers [4]. Most fallopian tube carcinomas present as papillary serous adenocarcinomas. The intraperitoneal spread of fallopian tube carcinomas is... 

One can also recognize some correlations between the subtype of tumor and the type of hormonal exposure. Unopposed hyperestrogenism is most likely to be associated with the endometrioid type of endometrial carcinoma, rather than with clear-cell, serous-papillary, and mucinous carcinomas. 

Armes JE, Lourie R, de SM, et al. Abnormalities of the RBI pathway in ovarian serous papillary carcinoma as determined by overexpression of the pl6(INK4A) protein. Int J Gynecol Pathol. 2005 24 363-368. 

Santin AD, Bellone S, Van SS, et al. Determination of HER2/ neu status in uterine serous papillary carcinoma Comparative analysis of immunohistochemistry and fluorescence in situ hy-btidization. Gynecol Oncol. 2005 98 24-30. 

Attanoos RL, Webb R, Dojcinov SD, et al. Value of mesothe-lial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary carcinoma of the ovary and peritoneum. Histopathology. 2002 40 237-244. 

Halperin R, Zehavi S, Hadas E, et al. Immunohistochemical comparison of primary peritoneal and primary ovarian serous papillary carcinoma. Int J Gynecol Pathol. 2001 20 341-345. 

Moritani S, Ichihara S, Hasegawa M, et al. Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WTl, CA125, and GCDEP-15 useful in differential diagnosis Hum Pathol. 2008 39 666-671. 

Comin CE, Saieva C, Messerini L. h-caldesmon, calretinin, estrogen receptor, and Ber-EP4 A useful combination of immuno-histochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am ] Surg Pathol. 2007 31 1139-1148. 

Von Hippel-Lindau disease (VHL) is an autosomal dominant condition secondary to an alteration in a tumor suppressor gene on chromosome 3. It has incomplete penetrance and is characterized by hemangioblastomas in the retina, CNS, renal cell carcinoma, endolymphatic sac tumors, pheochro-mocytomas, papillary cystadenoma of the epididymis, angiomas of the liver and kidney, cysts of the liver, kidney and epididymis, and pulmonary arteriovenous shunts (Fig. 4.18a-c). In the pancreas, VHL may have multiple presentations, the most common being the presence of multiple small pancreatic cysts with calcifications in 40% of cases. Serous cystad-enomas, solid nonfunctional islet cell tumors, and adenocarcinoma are less common (Richard et al. 2004). 

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