Endometrial serous carcinoma

The majority of endometrial serous carcinomas are negative for WTl positive cases generally show patchy staining. 

It is easy to recognize endometrial serous carcinoma when it is tumor forming and present in its characteristic papillary form with bizarre tumor cell nuclei. However, endometrial serous carcinoma can be difficult to diagnose... 

Einally, it should be noted that while many serous adenocarcinomas of endometrium resemble ovarian serous carcinomas, there are some important differences. We will discuss these differences in the Ovary section. The most important of these is infrequent WTl expression in endometrial serous carcinomas (seen in at most 20% to 30% of such cases) and the very common diffuse nuclear expression of WTI in ovarian, tubal, and primary peritoneal examples (at least 70% to 80% of such cases). 

Estrogen receptor (ER) Breast and endometrium carcinoma Ovarian serous, mucinous and endometrioid carcinoma. Breast and endometrial epithelium, endometrial stromal cells and... 

One can also recognize some correlations between the subtype of tumor and the type of hormonal exposure. Unopposed hyperestrogenism is most likely to be associated with the endometrioid type of endometrial carcinoma, rather than with clear-cell, serous-papillary, and mucinous carcinomas. 

Common in renal, endometrial, ovarian serous, salivary gland, follicular thyroid, and sarcomatoid (spindle cell) carcinomas, "basal-like" breast carcinomas, as well as in the epithelial and stromal components of malignant mixed mullerian tumors... 

Overexpression of the p53 tumor suppressor protein is seen in more than 80% of uterine serous carcinomas and in their putative precursor lesion, endometrial intraepithelial carcinoma The most com-... 

Ambros RA, Sherman ME, Zahn CM, et al. Endometrial intraepithelial carcinoma A distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol. 1995 26 1260-1267. 

Liang SX, Chambers SK, Cheng L, et al. Endometrial glandular dysplasia A putative precursor lesion of uterine papillary serous carcinoma. Part II molecular features. Int J Surg Pathol. 2004 12 319-331. 

Euscher ED, Malpica A, Deavers MT, et al. Differential expression of WT-l in serous carcinomas in the peritoneum with or without associated serous carcinoma in endometrial polyps. Am J Surg Pathol. 2005 29 1074-1078. 

Wilms tumor protein-1 (WT-1) Nephroblastoma, mesothelioma, metanephric adenoma, ovarian serous carcinoma AML, desmoplastic small round cell tumor, endometrial stromal sarcoma, uterine leiomyosarcoma, granulosa cell tumor, thecoma, rhabdoid tumor Kidney, mesothelial cells, granulosa cells, Sertoli cells, fallopian tube endometrial stroma, spleen... 

Lymph node dissection is also recommended in histological subtypes associated with a higher risk of lymph node metastasis (e.g., clear cell, serous papillary endometrial carcinoma). Pelvic lymph node dissection should be performed in combination with para-aortic lymph node dissection because of the high risk of metastasis at both sites [24]. Whether lymphadenectomy is curative in endometrial cancer remains controversial [38]. 

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