P toxicity

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Data on acute i.p. toxicity are available for YTX and eight analogues [3] (for chemistry, see Chapter 13). The LD50 or lethal dose values for YTX varies between 100 and 750 [tg/kg body weight. This is partly explained by possible differences in susceptibilities between mouse strains... 

The information on the acute toxicity of PTX-2 and analogues in mice by gavage is conflicting, but according to the Expert Consultation [3] it is much lower than their i.p. toxicities (>5000 [ig/kg body weight). Studies suggest that PTX-2 and PTX-2 SA are poorly absorbed from the gastrointestinal tract. 

Previous studies (Velez et al." ) indicated a good correlation between receptor-based assay (RBA) results and mouse i.p. toxicity (/ =. 97 V=41). In routine work performed between 1995 and 1997, the practical detection limit was 0.04 pg STX eq./lOO g, three orders of magnitude lower than the MBA, providing quantitative data below the detection level of the MBA and thus early warning measurements. Typically, 20-40 samples plus the standard curve, three internal positive controls and 1 negative control could be run per work shift using a conventional liquid scintillation counter. 

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