P-Dimethylaminoethyl chloride

Benzyl pyridine p-Dimethylaminoethyl chloride Potassium amide Maleic acid... 

P-DIMETHYLAMINOETHYL CHLORIDE HYDROCHLORIDE (Ethylamine, 2-chloro-N,N-dimethyl-, hydrochloride)... 

Tripelennamine can be prepared as follows 2-aminopyridine, prepared by the action of sodamide on pyridine, is reacted with P-dimethylaminoethyl chloride in the presence of sodamide, and the resulting 2-[2-(dimethylamino) ethylamino] pyridine is subsequently condensed with benzyl bromide in the presence of sodamide. The corresponding hydrochloride salt is obtained from the base by treatment with hydrogen chloride in an organic solvent. 

Cationic Starches. The two general categories of commercial cationic starches are tertiary and quaternary aminoalkyl ethers. Tertiary aminoalkyl ethers are prepared by treating an alkaline starch dispersion with a tertiary amine containing a P-halogenated alkyl, 3-chloto-2-hydtoxyptopyl radical, or a 2,3-epoxypropyl group. Under these reaction conditions, starch ethers are formed that contain tertiary amine free bases. Treatment with acid easily produces the cationic form. Amines used in this reaction include 2-dimethylaminoethyl chloride, 2-diethylaminoethyl chloride, and A/-(2,3-epoxypropyl) diethylamine. Commercial preparation of low DS derivatives employ reaction times of 6—12 h at 40—45°C for complete reaction. The final product is filtered, washed, and dried. 

Further substitution of benzoic acid leads to a drug with antiemetic activity. Alkylation of the sodium salt of p-hydroxy-benzaldehyde (8) with 2-dimethylaminoethyl chloride affords the so-called basic ether (9). Reductive amination of the aldehyde in the presence of ammonia gives diamine, 10. Acylation of that product with 3,4,5-trimethoxybenzoyl chloride affords trimetho-benzamide (11). ... 

A solution of 219 g (1 mol) of a-(p-chlorophenyl)-2-pyridinemethanol in one liter of dry toluene is heated to 100°C with stirring. Twenty-three grams (1 g-atom) of sodium are then added in portions. After all the sodium has reacted, a dried solution of 2-dimethylaminoethyl chloride in benzene is added. This benzene solution is prepared by dissolving 173 g (1.2 mols) of 2-dimethylaminoethyl chloride hydrochloride in the minimum amount of water, adding 500 cc of benzene followed by 300 g of sodium carbonate decahydrate, stirring, separating the benzene layer and drying. 

The chloroform layer was dried and evaporated to remove the solvent. The residue was dissolved in acetone, and an ethanol solution containing hydrogen chloride was added thereto producing 1.53 grams of 2-(4-methoxyphenyl)3-acetoxy-5-(p-dimethylaminoethyl)-2,3-dihydro-l,5-benzothiazepin-4(5H)-one hydrochloride having a melting point from 187° to 188°C. 

To 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams (1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and refluxed for 15 hours, then cooled and the precipitated sodium chloride filtered off. The filtrate was concentrated at steam temperature under water vacuum and the residual oil was fractionated in high vacuum, to give 4-(2-dimethylaminoethoxy)benzaldehyde, BP2.2145°C. 

SYNS AMBENYL BAX BENA BENADRYL BENDYLATE BENOCTEN BENZEHIST BENZ-HYDRAMINE HYDROCHLORIDE 2-(BENZHYDRYL-OXY)-N>l-DLMETHYLETHYL-AMINEHYDRO-CHLORIDE DABYLEN DIFENHYDRAMINE HYDROCHLORIDE DIMETHYLAMINE BENZHYDRYL ESTER HYDROCHLORIDE p-DIMETHYLAMINOETHYL BENZHYDRYL ESTER HYDROCHLORIDE DIPHENYLHYDRAMINE HYDROCHLORIDE 2-piPHENYLMETHOXY)-N,N-DIMETHYL-ETHANAMINE HYDROCHLORIDE 02-DIPHENYLMETHOXY-NJSI-DIMETHYLETHYLAMINE HYDROCHLORIDE DOLESTAN ELDADRYL FELBEN FENYLHIST HALBMOND O-HYDR-... 

SYNS CHLOROpiMETHYLAMINO)ETHANE p-CHLOROETHYLDIMETHYLAMINE (2-CHLORO-ETHYL)DIMETHYLAMINE DIMETHYLAMINOETHYL CHLORIDE p-(DIMETHYLAMINO)ETHYL CHLORIDE 2-DMETHYLAIVnNOETHYLCHLORIDE DIMETH-YL(2-CHLOROETHYL)AMINE HN 1 NITROGEN HALF MUSTARD... 

See di(p-chlorophenyl)ethanol. (2) Abbreviation for (3-dimethylaminoethyl chloride hydrochloride. 

Dimethylaminoethyl chloride hydrochloride Dimethyl (2-chloroethyl) amine hydrochloride Dimethyl-P-chloroethylamine hydrochloride DMC... 

Dimethyl-P-chloroethylamine hydrochloride. See Dimethylaminoethyl chloride hydrochloride... 

Monomers 4VP, 4-vinylpyridine NIPAAm, jV-isopropylacrylamidc AA, acrylic acid PEGMA, poly (ethylene glycol) methacrylate SPE, MAI-dimethyl-AW2-methacryloyloxycthyl-/V-0-sulfopropyl)amm<>-nium betaine AMPS, 2-acrylamido-2-methyl-l-propanesulfonic acid qDMAEMA, quaternary 2-dimethylaminoethyl methacrylate St, styrene HEMA, 2-hydroxyethyl methacrylate HEA, 2-hydro-xyethyl acrylate DMAEMA, 2-dimethylaminoethyl methacrylate MAA, methacrylicacid NaSS sodium p-styrene sulfonate AC, [(2-acryloyloxy)ethyl]trimethyl ammonium chloride GMA, glycidyl methacrylate NVP, jV-vinylpyrrolidone MAn, maleic anhydride BVE n-butyl vinyl ether AAm, acrylamide DEAAm, MA-diethylacrylamidc DMAAm, MA -dimethylacrylamidc MMA, methyl methacrylate. 

A soln. of 2-benzyl-4-cresol in toluene added gradually to a suspension of NaH in toluene, refluxed 30 min., and to the gently refluxing soln. so obtained / -dimethylaminoethyl phloride, dissolved in toluene, added dropwise —2-benzyl-4-tolyl-y3-dimethylaminoethyl ether. Y 89%.—In the case of phenols containing a basic function, only the theoretical amount of the chloride was used in order to minimize quaternary formation (p. 3795). (F. e. s. W. B. Wheatley, L. C. Cheney, and S. B. Binkley, Am. Soc. 71, 64, 3795 (1949).)... 

CH2CH2C02CH2Ph l-Ethyl-3-phenyl p-toluenesulfonate l-(2-Dimethylaminoethyl)-2,3-diphenyl chloride hydrochloride Hemiethanolate... 

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