4-chlorophenyl-2-ethanol

Chlorfenethol [80-08-6] l,l-bis(p-chlorophenyl)ethanol, R = H (139), is a white soHd (mp 70°C). The compound is readily dehydrated upon heating or in the presence of strong acids and forms the inactive l,l-bis( chlorophenyl)ethylene. Chlorfenethol is active against all stages of mites. It has an oral LD q to the rat of ca 200 mg/kg. 

Thirty-five microorganisms isolated from marine sediment and marine water samples taken from Hawaii and Houston, TX were capable of degrading p,p- DDT. jO,//-DDD was identified as the major metabolite. Minor transformation products included 2,2-bis(/t-chlorophenyl)-ethanol (DDOH), 2,2-bis(/t-chlorophenyl)ethane, and p,p-DDE (Path et al., 1972). 

The conversion of 2-(o-chlorophenyl)-ethanol to dihydrobenzofurane was also promoted by copper(I) chloride in toluene in the presence of sodium hydride (3.44.), The choice of solvent was crucial to suppress undesired side reactions, such as dehydration or the loss of a formaldehyde fragment.54... 

Purify the crude product by chromatography using pentane ether (4 1). Pure 2,2,2-trifluoro-1-(4-chlorophenyl)ethanol is obtained (3.79 g, 90%) and characterized by H and 13C NMR. 

IUPAC name 2,2,2-trichloro-l,l-bis(4-chlorophenyl)ethanol Molecular formula C14H9CI15O... 

Figure 18.7. Enzymatic preparation of (S)-2-chloro-l-(3-chlorophenyl)ethanol.

TRICHLORO-l,l-BIS(4-CLORO-FENIL)-ETANOLO (ITALIAN) 2,2,2-TRICHLORO-l,l-DI-(4-CHLOROPHENYL)ETHANOL... 

See di(p-chlorophenyl)ethanol. (2) Abbreviation for (3-dimethylaminoethyl chloride hydrochloride. 

In 1980, another in vivo conjugation of fatty acids to a hydroxylated toxin was identified. Palmitic, stearic, oleic, and linoleic fatty acid conjugates of a 2,2-bls( -chlorophenyl)-ethanol metabolite (DDOH) were isolated from the livers and spleens of DDT-treated male and female rats ( ). 

Equilibrium distribution coefficient (log P or log D) is an important parameter to assess the solvent effect. Asymmetric reduction of 4-chloroacetophenone to (R)-l-(4-chlorophenyl)ethanol by Lactobacillus kefir showed an increase in product yield with increase in log D value of the ILs [104]. However, auother study [117], which used ILs as coating of lipase (Novozyme 435) for esterification of methyl a-o-glucopyranoside with fatty acids, showed a remarkable increase in the product yield with increase in the polarity of the IL used for coating which is opposite in trend to that observed when ILs were used as solvent as discussed above. This altered effect of more polar IL coating on product yield was attributed to their better absorption ability on the polyacrylate beads used for immobilization of enzymes in this case [117]. 

The following members of this group attained practical importance l,l-bis(4-chlorophenyl)ethanol (chlorfenethol, 2), l,l-bis(4-chlorophenyl)-cyclopropyl-methanol (prochlonol, 3) and I,l-bis(4-chlorophenyl)-2,2,2-trichloroethanol (dicofol, 4). 

AchE—acetylcholinesterase dichloroethylene DDT — 1 di(4-chlorophenyl) ethanol matic hydrocarbons TCDD... 

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