P300

Cytokines such as TNFa and IL-1 3, acting via NF-kB, can induce histone acetylation in both a time- and concentration-dependent manner. Upon DNA binding, NF-kB recruits transcriptional coactivators such as CREB binding protein (CBP) and p300/CBP-associated factor (PCAF). 

Figure 43-11. The hormone response transcription unit. The hormone response transcription unit is an assembly of DNA elements and bound proteins that interact, through protein-protein interactions, with a number of coactivator or corepressor molecules. An essential component is the hormone response element which binds the ligand (A)-bound receptor (R). Also Important are the accessory factor elements (AFEs) with bound transcription factors. More than two dozen of these accessory factors (AFs), which are often members of the nuclear receptor superfamily, have been linked to hormone effects on transcription. The AFs can interact with each other, with the liganded nuclear receptors, or with coregulators. These components communicate with the basal transcription complex through a coregulator complex that can consist of one or more members of the pi 60, corepressor, mediator-related, or CBP/p300 families (see Table 43-6).

Figure 43-13. Several signal transduction pathways converge on CBP/p300. Ligands that associate with membrane or nuclear receptors eventually converge on CBP/p300. Several different signal transduction pathways are employed. EGF, epidermal growth factor GH, growth hormone PrI, prolactin TNF, tumor necrosis factor other abbreviations are expanded in the text.

Benkirane M, Chun RF, Xiao H, Ogryzko VV, Howard BH, Nakatani Y, Jeang KT (1998) Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat. J Biol Chem 273(38) 24898-24905... 

Fuiia B, Deng L, Wu K, Baylor S, Kehn K, Li H, DonneUy R, Coleman T, Kashanchi F (2002) Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins. J Biol Chem 277(7) 4973 980... 

Marzio G, Tyagi M, Gutierrez MI, Giacca M (1998) HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc Natl Acad Sd USA95(23) 13519-13524... 

However, the effects were more marked for ginseng and were accompanied by reductions in frontal alpha waveband activity and decreased latency of the P300 component of the auditory evoked potential, a result that suggests more efficient stimulus assessment. 

The participation of the different cofactors that form part of the transcription machinery is not homogeneous. Some, like pl60, can interact with both transcription activator domains of the receptor, TAF1 and TAF2, even though they utilize different pi60 domains. Others, like CBP/p300, do not enter into... 

Fig. 13.1 Stability regulation of p53 by early vs. late RNI actions. RNI by (in)directly activating ATR/ATM provoke phosphorylation ofp53. In turn tetramerization of p53 and binding of the coactivator p300/CBP will provoke gene activation. This may go along with RNI-evoked nuclear retention of ubiquitinated p53 although...

Fig. 13.3 HIF-la and p53 as mediators of RNI signaling. RNI affect HIF-la stabilization to promote its interaction with HIF-ip. Recruitment ofthe coactivator p300/CBP causes gene activation to elicit pathophysiological responses. RNI activate...

Araki, S. (1992). Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper Effects of lead on cognitive function and central nervous system. Amer. J. bid. M (Ed.), 21(4) 39-547. 

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