Coactivators p300/CBP

Fig. 13.1 Stability regulation of p53 by early vs. late RNI actions. RNI by (in)directly activating ATR/ATM provoke phosphorylation ofp53. In turn tetramerization of p53 and binding of the coactivator p300/CBP will provoke gene activation. This may go along with RNI-evoked nuclear retention of ubiquitinated p53 although...

Fig. 13.3 HIF-la and p53 as mediators of RNI signaling. RNI affect HIF-la stabilization to promote its interaction with HIF-ip. Recruitment ofthe coactivator p300/CBP causes gene activation to elicit pathophysiological responses. RNI activate...

Cytokines such as TNFa and IL-1 3, acting via NF-kB, can induce histone acetylation in both a time- and concentration-dependent manner. Upon DNA binding, NF-kB recruits transcriptional coactivators such as CREB binding protein (CBP) and p300/CBP-associated factor (PCAF). 

Ogryzko VV, Schiltz RE, Russanova V, Howard BH, Nakatani Y (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87 953-959 Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, 3rd, Desai A, Fukagawa T (2006) The CENP-H-1 complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol 8 446-457... 

ACTR/RAC3 and p/cip A receptor-associated cofactor 3 (RAC3) was cloned as a coactivator for the liganded receptor LBD (69) and found to be identical to another coactivator named ACTR, which was known to possess intrinsic HAT activity (70). Sequence comparison revealed a homology to the SRC-1 and TIFII members (69) therefore, it was also categorized in the SRC family. A closely related coactivator, the p300/CBP cointegrator associated protein (p/CIP), was found to interact with CBP and was required for the actions of CBP-dependent transcription factors (71). These members represent the third SRC family that functions as coactivators for RARs and RXRs, and possesses HAT activity. 

Janknecht R (2002) The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol 17(2) 657-668... 

The pl60 family of coactivators including steroid receptor coactivator 1 (SRC-1), TIF/GRIP (SRC-2), and ACTR/pCIP (SRC-3) [24] stimulates the transcriptional activity of nuclear receptors. The pi60 family of coactivators has three LXXLL motifs in the receptor-interacting domain (RID) that interacts with the AF-2 domain of nuclear receptors. SRC-1 is a weak HAT that interacts with p300/CBP and recruits CARM-1. 

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