P300/CBP-associated factor

Cytokines such as TNFa and IL-1 3, acting via NF-kB, can induce histone acetylation in both a time- and concentration-dependent manner. Upon DNA binding, NF-kB recruits transcriptional coactivators such as CREB binding protein (CBP) and p300/CBP-associated factor (PCAF). 

Trievel, R.C., Li, F.Y. and Marmorstein, R. (2000) Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/ CBP-associated factor. Analytical Biochemistry, 287, 319-328. 

Overall, the physiological function of individual TAFs is still incompletely imder-stood. The situation is complicated by the fact that a subset of the TAFs, including the histone-like TAFs, have been identified as components of a large histone acetylase complex, termed SAGA in yeast and PCAF (p300/CBP associated factor) in humans (see 1.4.6). 

X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, and Y. Nakatani. A p300/CBP-associated factor that competes with the adenoviral oncoprotein ElA. Nature, 382 (6589), 319-324, 1996. 

PCAF p300/CBP-associated factor, a histone acetyltransferase... 

In addition to UBF, SL1 has been shown to be the substrate of cellular acetylases. This study was prompted by the indication that PCAF, a p300/ CBP associated factor with acetyltransferase activity, is recruited to the... 

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