Oxybutynin chloride

Ciba Limited, Switzerland British Patent 1,077,603 August 2,1967 [Pg.1143]

Chemical Name a-cyclohexyl-a-hydroxybenzeneacetic acid 4-(dietl ylamino)-2-butynyl ester hydrochloride [Pg.1143]

Chemical Abstracts Registry No. 1508-65-2 5633-20-5 (Base) Trade Name Manufacturer [Pg.1143]

Methyl phenylcyclohexylglycolate 4-Diethylamino-2-butynyl acetate Sodium methylate [Pg.1143]

About 314 hours were required for the reaction to be completed. [Pg.1143]

The reaction mixture was then allowed to cool to room temperature, washed with water, and extracted with four 165 ml portions of 2 N hydrochloric acid. The aqueous extracts were combined and stirred at room temperature to permit crystallization of the hydrochloride salt of the desired product. Crystallization was completed by cooling the slurry in an ice bath, and the product was collected by filtration, pressed dry, and recrystallized from 750 ml of water. Yield of pure crystalline material, 323 grams. [Pg.1143]

Diethylamino-4-aminopentane Chloroquine phosphate 4-Diethylamino-2-butynyl acetate Oxybutynin chloride 2-Diethylamino-1 -chloroethane Bietaserpine Fenoxedil... [Pg.1628]

Appel, R.A., Sand, P., Dmochowski, R., et al., (2000). Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the tteatment of overactive bladder results of the Object Study. Mayo Clin Proc 78 358-363. [Pg.697]

Smooth muscle relaxants flavoxate hydrochloride oxybutynin chloride tolterodine L-tartrate... [Pg.624]

Goldenberg, M.M. 1999. An extended-release formulation of oxybutynin chloride for the treatment of overactive urinary bladder. Clin Ther 21 634. [Pg.438]

Anderson, R.U., et al. 1999. Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence. J Urol 161 1809. [Pg.438]

Brendler, C.B., et al. 1989. Topical oxybutynin chloride for relaxation of dysfunctional bladders. J Urol 141 1350. [Pg.438]

Ditropan XL Procardia XL Glucotrol XL Alpress XL (France) Cardura XL (Germany) Concerta Covera HS DynaCirc CR Oxybutynin chloride Nifedipine Glipizide Prazosin Doxazosin mesylate Methylphenidate HC1 Verapamil HC1 Isradipine... [Pg.226]

Oral polio vaccine (verocell) Orthoclone sterile (OKT3) Oxaliplatin injection Oxiconazole Oxybutynin chloride Paclitaxel injection... [Pg.591]

Chancellor MB, Appell RA, Sathyan G, Gupta SK. A comparison of the effects on saliva output of oxybutynin chloride and tolterodine tartrate. Clin Ther 2001 23(5) 753-60. [Pg.2650]

Ditropan XL (oxybutynin chloride) once-a-day extended-release tablet for the treatment of overactive bladder characterized by symptoms of urinary incontinence, urgency, and frequency. [Pg.369]

Unlike oxybutynin IR, oxybutynin XL delivers a controlled amount of oxybutynin chloride continuously throughout the gastrointestinal tract over a 24-hour time period, reducing first-pass metabolism by cytochrome P450 (CYP450) isoenzyme 3 A4, which is... [Pg.1554]

Tapp AJ, Cardozo LD, Versi E, Cooper D. The treatment of detrusor instability in post-menopausal women with oxybutynin chloride A double blind placebo controlled study. Br J Obstet Gynaecol 1990 97 1063-1064. [Pg.1562]

Riva D, Casolati E. Oxybutynin chloride in the treatment of female idiopathic bladder instability. Clin Exp Obstet Gynecol 1984 11 37-42. [Pg.1562]

Schmidt RA, The Oxybutynin XL Study Group. Efficacy of controlled-release, once-a-day oxybutynin chloride for urge urinary incontinence. Jerusalem, International Continence Society, Sept. 14—17, 1998 188. [Pg.1562]

ALZA Corporation. Ditropan XL (oxybutynin chloride) extended-release tablets. Data on file. Palo Alto, CA, 1999. [Pg.1562]

Katz IR, Sands LP, Bilker E, et al. Identification of medications that cause cognitive impairment in older people The case of oxybutynin chloride. J Am Geriatr Soc 1998 46 8-13. [Pg.1562]

Susset JG, Gleason DM, White CF, et al. Open-label safety and dose conversion/determination of once-daily OROS oxybutynin chloride for mge urinary incontinence. J Urol 1998 159(Suppl) 36. [Pg.1562]

Dicyclomine hydrochloride (Bentyl, others), flavoxate hydrochloride (Urispas, others), oxybutynin chloride (Ditropan, others), and tolterodine tartrate (Detrol) are tertiary amines and trospium chloride (Sanctura) is a quaternary amine all are used for their anfispasmodic properties. These agents appear to exert some nonspecific direct relaxant effect on smooth muscle. In therapeutic doses, they decrease spasm of the G1 tract, biliary tract, ureter, and uterus. [Pg.199]

Oxybutynin chloride is an anticholinergic that increases bladder capacity, diminishes frequency of uninhibited contractions of detrusor muscle and delays initial desire to void. It is indicated in the treatment of symptoms of bladder instability associated with voiding in patients with uninhibited and reflex neurogenic bladder (e.g., urinary leakage, dysuria) and treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. [Pg.531]

Oxybutynin Chloride, a -Cyclohexyl.a. hydroxy-benzeneacetic acid 4 idiethylamino)-2-butynyl ester hydrochloride, a -phenylcyclohexaneglycolic acid 4-idiethylomino) -2 butynyl ester hydrochloride 4-diethylamino-2-butynyl phenylcyclohexylglycolate hydrochloride oxibutinina by-drochloride Ditropan Dridase Pollakisu Tropax. -... [Pg.1100]

Cystrin Ditropan Dridase EINECS 216-139-7 MJ-4309-1 Oxibutinina hydrochloride Oxybutynin chloride Oxybutynin hydrochloride Pollakisu Tropax. Anti-cholinergic. Crystals mp = 129-130° LDso (rat orl) = 1220 mg/kg. Hoechst AG (USA). [Pg.464]

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