Neurogenic bladder

Several risk factors are known to exist in men and women. The common risk factors for UTI in women include sexual intercourse, lack of voiding after intercourse, use of a diaphragm, use of spermicidal jellies, diabetes, and pregnancy. In men, the risks are different, and are primarily centered on lack of circumcision, and at an older age include prostatic hyperplasia. Common risk factors for both men and women include urologic instrumentation, renal transplantation, neurogenic bladder, and urinary tract obstruction.26... 

Therapeutic action of this dmg is based on this action, and it is used for treating post-operational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer s disease. Synonyms of this drug are duvoid, miotonin, and urecholine. 

Bladder instability/Overactive bladder For the relief of symptoms of bladder instability/treatment of overactive bladder associated with voiding in patients with uninhibited and reflex neurogenic bladder (eg, urgency, freguency, urinary leakage, urge incontinence, dysuria). 

Urogenital tract Uninhibited hypertonic neurogenic bladder. 

Neurogenic Bladder PO 2.5-5 mg twice a day. May increase by 2.5 mg/day every 1-2 days. PO (Extended-Release) 5-10 mg/day up to 30 mg/day. Transdermal 3.9 mg applied twice a week. Apply every 3-4 days. 

The major therapeutic uses of the cholinomimetics are for diseases of the eye (glaucoma, accommodative esotropia), the gastrointestinal and urinary tracts (postoperative atony, neurogenic bladder), the neuromuscular junction (myasthenia gravis, curare-induced neuromuscular paralysis), and very rarely, the heart (certain atrial arrhythmias). Cholinesterase inhibitors are occasionally used in the treatment of atropine overdosage. Several newer cholinesterase inhibitors are being used to treat patients with Alzheimer s disease. 

Useful for some diabetic patients with neurogenic bladder dysfunction. 

Atropine Generic Peptic ulcer, irritable bowel syndrome, neurogenic bladder, bronchospasm, preoperative antisecretory agent, cardiac arrhythmias (e.g., sinus bradycardia, postmyocardial infarction, asystole], reversal of neuromuscular blockade, antidote to cholinesterase inhibitor poisoning... 

Urinary Tract. Atropine and several synthetic antimuscarinics have been used to alleviate urinary frequency and incontinence caused by hypertonicity of the urinary bladder.13,17 Increased bladder tone results if the normal reflex control of bladder function is disrupted (i.e., the so-called neurogenic bladder syndrome) or a urinary tract infection irritates the bladder. Some people might also exhibit increased urinary... 

Nonneoplastic forms Prostatic hypertrophy Renal tuberculosis Renal lithiasis Calculi of the bladder Cystic diseases Urethral stricture Hypospadias Neurogenic bladder Nephritis... 

Sensory neuropathy occurred in a 58-year-old man who had been given up to 2400 mg/day for over 5 months for the treatment of head pain (12). A mild pruritic rash had been present since starting treatment. Neuropathic symptoms included a burning sensation in the legs and hips. After withdrawal, reduced perception of tactile and noxious stimuli and neurogenic bladder dysfunction (with an associated syncopal episode) were recorded. The neuropathy improved over several months. 

Trade names Albert (Oxybutynin) Cystrin Ditropan (Ortho-McNeil) Dridase Novitropan Oxyban Tropax Indications Neurogenic bladder, urinary incontinence Category Anticholinergic Muscarinic antagonist Half-life 1-2.3 hours... 

Buyse G, Waldeck K, Ver C, et al. Intravesical oxybutynin for neurogenic bladder Less systemic side effects due to reduced first-pass metabolism. J Urol 1998 160 892-896. 

Other Weight loss or gain, chemical skin burns, neurogenic bladder dysfunction... 

Methenamine, a urinary tract antiinfective agent, is used in long-term prophylaxis or snppression of chronic urinary tract infections (methenamine hippnrate), and in the treatment of urinary tract infections associated with neurogenic bladder. 

Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating. If tachycardia is excessive, it may also be necessary to use a beta-blocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstraction, and partial prostatic obstruction. 

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