Overdosage or underdosage

Admixtures should be purchased under specifications that stipulate the desired properties, exclude adverse effects and provide evaluation of uniformity of the admixture from batch to batch. The user should ensure that the admixtures being considered conform to ASTM or other applicable specifications and the manufacturer of the admixture should be required to certify that individual lots meet the requirements of applicable standards or specifications. The following information should be provided by the admixture manufacturer or supplier (1) composition of the admixture in terms of the generic type of its main constituents (2) incompatibility with other admixtures or special cements (3) typical dosage (4) detrimental effects of overdosage or underdosage (5) chloride content and (6) whether air is entrained at the recommended dosage. 

Elderly people are particularly likely to make errors in the administration of ophthalmic medications, resulting in overdosage and adverse toxic effects or underdosage with inadequately controlled glaucoma (12). This may reflect impaired memory, mental confusion, impaired vision, hearing, and mobility, or a combination of these factors. It is wise to assess both adherence to therapy and administration technique to ensure the safe and effective use of... 

These profiles can be used to control the day-to-day performance of the assay and also to optimise its design in relation to imprecision at medical decision points relating to underdosage or overdosage of patients. 

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